Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2744181..2744695 Replicon chromosome
Accession NZ_CP051482
Organism Staphylococcus aureus strain NGA104a

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag HGO93_RS13545 Protein ID WP_000581793.1
Coordinates 2744486..2744695 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HGO93_RS13540 Protein ID WP_000138932.1
Coordinates 2744181..2744474 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO93_RS13520 (2739643) 2739643..2740284 + 642 WP_000483155.1 thiamine phosphate synthase -
HGO93_RS13525 (2740370) 2740370..2741242 + 873 WP_000725802.1 membrane protein insertase YidC -
HGO93_RS13530 (2741856) 2741856..2742503 - 648 WP_001187628.1 HD domain-containing protein -
HGO93_RS13535 (2742531) 2742531..2744015 - 1485 WP_000571549.1 cardiolipin synthase -
HGO93_RS13540 (2744181) 2744181..2744474 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HGO93_RS13545 (2744486) 2744486..2744695 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
HGO93_RS13550 (2744823) 2744823..2744960 + 138 WP_000828354.1 Lmo0850 family protein -
HGO93_RS13555 (2745223) 2745223..2746425 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
HGO93_RS13560 (2746743) 2746743..2747813 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
HGO93_RS13565 (2747828) 2747828..2749186 + 1359 WP_054193129.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T154249 WP_000581793.1 NZ_CP051482:2744486-2744695 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T154249 NZ_CP067420:4239499-4239786 [Skermanella sp. TT6]
GTGGTGGTGCTTGAGTGGCGGGAGACGGCCCGTGCCGATCTTTTGTCTATCATTGACTACATATCCGACGATAACTTGGA
GGCTGCCCAGCGTTTGAAAAACGACATCGAGGCGAAGACTTCGAAACTGCCTGAGCATCCGAAGCTCTACCGGACCGGTC
GAGTCGCTGGCACGCGGGAAATGGTTGTCCGATCTAACTACGTGGTCGTCTACACAGAAGACACGCGCGCAGTAACGATA
CTTCGCGTACTACATGCCGCCCAACAATGGCCGCCTGTGCACGAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT154249 WP_000138932.1 NZ_CP051482:2744181-2744474 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT154249 NZ_CP067420:4239213-4239512 [Skermanella sp. TT6]
ATGGCTGCCCAGACATCGATGCTGCACATCCGCGTGGACGACAAGCTCAAGGCTGACGCAACGGAAAAACTCGCCAATGT
CGGCCTCACTGTCTCGGATGCCGTACGTATCCTGCTTACGCGCATCGCCAAAGAAGGCGCTCTGCCGGCCGGATTGACCG
CGACACCCGAAGCGTATGATGCATGGTTTCGGGCCAAGGTCCACGAGGCGTTGGCCGACACAAGCCCGACGGCACCTCAT
CAGCAAGTCATGGGCGAAGCTCAAGCCTTGATCGACAGGAAACGTCGTGGTGGTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References