Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1206612..1207089 Replicon chromosome
Accession NZ_CP051482
Organism Staphylococcus aureus strain NGA104a

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HGO93_RS06080 Protein ID WP_000052076.1
Coordinates 1206901..1207089 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HGO93_RS06075 Protein ID WP_001059690.1
Coordinates 1206612..1206872 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO93_RS06040 (1202007) 1202007..1202723 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
HGO93_RS06045 (1202871) 1202871..1203293 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
HGO93_RS06050 (1203692) 1203692..1204186 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
HGO93_RS06055 (1204341) 1204341..1204958 + 618 Protein_1167 LysE/ArgO family amino acid transporter -
HGO93_RS06060 (1205031) 1205031..1205612 - 582 WP_001140696.1 histidine phosphatase family protein -
HGO93_RS06065 (1205836) 1205836..1206072 + 237 WP_000368687.1 hypothetical protein -
HGO93_RS06070 (1206069) 1206069..1206272 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HGO93_RS06075 (1206612) 1206612..1206872 + 261 WP_001059690.1 hypothetical protein Antitoxin
HGO93_RS06080 (1206901) 1206901..1207089 + 189 WP_000052076.1 hypothetical protein Toxin
HGO93_RS06085 (1207277) 1207277..1207846 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
HGO93_RS06090 (1207934) 1207934..1208218 + 285 WP_001004401.1 hypothetical protein -
HGO93_RS06095 (1208280) 1208280..1208498 + 219 WP_000005886.1 hypothetical protein -
HGO93_RS06100 (1208994) 1208994..1209194 - 201 WP_001059082.1 cold-shock protein -
HGO93_RS06105 (1209551) 1209551..1210237 - 687 WP_001793574.1 thermonuclease family protein -
HGO93_RS06110 (1210578) 1210578..1211099 - 522 WP_000824464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / clfA 1205836..1234041 28205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T154240 WP_000052076.1 NZ_CP051482:1206901-1207089 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T154240 NZ_CP067417:c2117363-2116053 [Aeromonas media]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGCATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCATGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCCATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGGCGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAACTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTGCAGATTCAATTTTGGGTGGACT
CAGTTCGAAAGCGCAACGCTTAAAACGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT154240 WP_001059690.1 NZ_CP051482:1206612-1206872 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT154240 NZ_CP067417:c2117617-2117363 [Aeromonas media]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References