Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsaAT/-
Location 1206612..1207089 Replicon chromosome
Accession NZ_CP051482
Organism Staphylococcus aureus strain NGA104a

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HGO93_RS06080 Protein ID WP_000052076.1
Coordinates 1206901..1207089 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HGO93_RS06075 Protein ID WP_001059690.1
Coordinates 1206612..1206872 (+) Length 87 a.a.

Genomic Context


HGO93_RS06045HGO93_RS06050HGO93_RS06055HGO93_RS06065HGO93_RS06075HGO93_RS06080HGO93_RS06085HGO93_RS06090HGO93_RS06095HGO93_RS06040HGO93_RS06060HGO93_RS06070HGO93_RS06100HGO93_RS06105HGO93_RS06110
Location: 1202871..1203293 (423 bp)
Type: Others
Protein ID: WP_000974460.1
Location: 1203692..1204186 (495 bp)
Type: Others
Protein ID: WP_000569884.1
Location: 1204341..1204958 (618 bp)
Type: Others
Protein ID: Protein_1167
Location: 1205836..1206072 (237 bp)
Type: Others
Protein ID: WP_000368687.1
Location: 1206612..1206872 (261 bp)
Type: Antitoxin
Protein ID: WP_001059690.1
Location: 1206901..1207089 (189 bp)
Type: Toxin
Protein ID: WP_000052076.1
Location: 1207277..1207846 (570 bp)
Type: Others
Protein ID: WP_001106654.1
Location: 1207934..1208218 (285 bp)
Type: Others
Protein ID: WP_001004401.1
Location: 1208280..1208498 (219 bp)
Type: Others
Protein ID: WP_000005886.1
Location: 1202007..1202723 (717 bp)
Type: Others
Protein ID: WP_000150012.1
Location: 1205031..1205612 (582 bp)
Type: Others
Protein ID: WP_001140696.1
Location: 1206069..1206272 (204 bp)
Type: Others
Protein ID: WP_000145163.1
Location: 1208994..1209194 (201 bp)
Type: Others
Protein ID: WP_001059082.1
Location: 1209551..1210237 (687 bp)
Type: Others
Protein ID: WP_001793574.1
Location: 1210578..1211099 (522 bp)
Type: Others
Protein ID: WP_000824464.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HGO93_RS06040 (1202007)1202007..1202723-717WP_000150012.1type I 3-dehydroquinate dehydratase-
HGO93_RS06045 (1202871)1202871..1203293+423WP_000974460.1organic hydroperoxide resistance protein-
HGO93_RS06050 (1203692)1203692..1204186+495WP_000569884.1GNAT family N-acetyltransferase-
HGO93_RS06055 (1204341)1204341..1204958+618Protein_1167LysE/ArgO family amino acid transporter-
HGO93_RS06060 (1205031)1205031..1205612-582WP_001140696.1histidine phosphatase family protein-
HGO93_RS06065 (1205836)1205836..1206072+237WP_000368687.1hypothetical protein-
HGO93_RS06070 (1206069)1206069..1206272-204WP_000145163.1sterile alpha motif-like domain-containing protein-
HGO93_RS06075 (1206612)1206612..1206872+261WP_001059690.1hypothetical proteinAntitoxin
HGO93_RS06080 (1206901)1206901..1207089+189WP_000052076.1hypothetical proteinToxin
HGO93_RS06085 (1207277)1207277..1207846+570WP_001106654.1lipoprotein N-acylation protein LnsA-
HGO93_RS06090 (1207934)1207934..1208218+285WP_001004401.1hypothetical protein-
HGO93_RS06095 (1208280)1208280..1208498+219WP_000005886.1hypothetical protein-
HGO93_RS06100 (1208994)1208994..1209194-201WP_001059082.1cold-shock protein-
HGO93_RS06105 (1209551)1209551..1210237-687WP_001793574.1thermonuclease family protein-
HGO93_RS06110 (1210578)1210578..1211099-522WP_000824464.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage-vWbp / clfA1205836..123404128205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(150-402)

Antitoxin

(13-65)


Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T154240 WP_000052076.1 NZ_CP051482:1206901-1207089 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T154240 NZ_CP067417:c2117363-2116053 [Aeromonas media]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGCATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCATGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCCATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGGCGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAACTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTGCAGATTCAATTTTGGGTGGACT
CAGTTCGAAAGCGCAACGCTTAAAACGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT154240 WP_001059690.1 NZ_CP051482:1206612-1206872 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT154240 NZ_CP067417:c2117617-2117363 [Aeromonas media]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0VP18


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VN56

References