Detailed information of TA system TA154237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 120516..121292
• Replicon: chromosome
• Accession: NZ_CP051482
• Organism: Staphylococcus aureus strain NGA104a

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: HGO93_RS00775
• Protein ID: WP_000031108.1
• Coordinates: 121140..121292 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: HGO93_RS00770
• Protein ID: WP_001251224.1
• Coordinates: 120516..121115 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO93_RS00750 (116432)	116432..117889	+	1458	WP_054192983.1	ABC transporter permease subunit	-
HGO93_RS00755 (117882)	117882..118604	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
HGO93_RS00760 (118755)	118755..119882	+	1128	WP_000379987.1	tRNA epoxyqueuosine(34) reductase QueG	-
HGO93_RS00765 (119887)	119887..120357	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
HGO93_RS00770 (120516)	120516..121115	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
HGO93_RS00775 (121140)	121140..121292	+	153	WP_000031108.1	SAS053 family protein	Toxin
HGO93_RS00780 (121898)	121898..122293	+	396	WP_000901023.1	hypothetical protein	-
HGO93_RS00785 (122489)	122489..123874	+	1386	WP_000116229.1	class II fumarate hydratase	-
HGO93_RS00790 (124335)	124335..125156	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	120516..202780	82264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T154237 WP_000031108.1 NZ_CP051482:121140-121292 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T154237 NZ_CP067413:c4659147-4658860 [Raoultella ornithinolytica]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCAGCAAGCAATCTAAGAAAACATGGGATTCGGTTCGAGGAGGCGGT
ACTGGTTTTTGACGATCCGCAGCACCTTTCCCGCCAGGATCGTTATGAAAACGGTGAGTATCGATGGCAAACCATCGGCC
TCGTTCATGGAATTATCGTTATTCTTGTGGCGCATTCGGTCCGTTTTGAAAGCGGGGCTGAGGTGATTCGTATCATCAGC
GCCCGGAAGGCGGACAAAAAAGAGAGGAGTCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT154237 WP_001251224.1 NZ_CP051482:120516-121115 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT154237 NZ_CP067413:c4658873-4658568 [Raoultella ornithinolytica]
ATGAGCATGGTTAAACATAAACGCGATAACCCGACAGCGCTTACCGCTCAGCGTGAAGACGAACTCAAAGCGCTGGCGAA
AAAATCAGATGATGACATTGATTACAGTGACATCCCCTCTTCGGACGATGAGCCGTGGTCAGAGGCGGTTCGCGGTAAAT
TTTATCGGCCATTAAAAACGCAGGCCTCTGTGCGCATCGATGCAGATGTGATGGAGTGGCTTAAACGCCCGGGAAAAGGC
TATCAAACGCGGCTGAACGCGATTCTGCGGGAAGCCATGCTGCGCGAGCAGAATAAGAAATCGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4