154233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2717345..2717874 Replicon chromosome
Accession NZ_CP051479
Organism Staphylococcus aureus strain NGA76

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HF085_RS13410 Protein ID WP_000621175.1
Coordinates 2717512..2717874 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag HF085_RS13405 Protein ID WP_000948331.1
Coordinates 2717345..2717515 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF085_RS13375 (2712381) 2712381..2712941 + 561 WP_001092416.1 K(+)-transporting ATPase subunit C -
HF085_RS13380 (2713150) 2713150..2713629 + 480 WP_001287090.1 hypothetical protein -
HF085_RS13385 (2713622) 2713622..2715205 + 1584 WP_001294626.1 PH domain-containing protein -
HF085_RS13390 (2715192) 2715192..2715683 + 492 WP_001205910.1 PH domain-containing protein -
HF085_RS13395 (2715687) 2715687..2716046 + 360 WP_000581200.1 holo-ACP synthase -
HF085_RS13400 (2716112) 2716112..2717260 + 1149 WP_001281151.1 alanine racemase -
HF085_RS13405 (2717345) 2717345..2717515 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
HF085_RS13410 (2717512) 2717512..2717874 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HF085_RS13415 (2718223) 2718223..2719224 + 1002 WP_061839378.1 PP2C family protein-serine/threonine phosphatase -
HF085_RS13420 (2719343) 2719343..2719669 + 327 WP_001052491.1 anti-sigma factor antagonist -
HF085_RS13425 (2719671) 2719671..2720150 + 480 WP_001190829.1 anti-sigma B factor RsbW -
HF085_RS13430 (2720125) 2720125..2720895 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T154233 WP_000621175.1 NZ_CP051479:2717512-2717874 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T154233 NZ_CP067413:1992265-1992368 [Raoultella ornithinolytica]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT154233 WP_000948331.1 NZ_CP051479:2717345-2717515 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT154233 NZ_CP067413:c1992373-1992207 [Raoultella ornithinolytica]
CAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGCGTCAGGTTTTCCAGTCCGCAACAAAAGTGGT
CGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References