154232

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2697620..2698134 Replicon chromosome
Accession NZ_CP051479
Organism Staphylococcus aureus strain NGA76

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag HF085_RS13320 Protein ID WP_000581793.1
Coordinates 2697925..2698134 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HF085_RS13315 Protein ID WP_000138932.1
Coordinates 2697620..2697913 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF085_RS13295 (2692984) 2692984..2693625 + 642 WP_000483164.1 thiamine phosphate synthase -
HF085_RS13300 (2693711) 2693711..2694583 + 873 WP_000725802.1 membrane protein insertase YidC -
HF085_RS13305 (2695295) 2695295..2695942 - 648 WP_001187627.1 HD domain-containing protein -
HF085_RS13310 (2695970) 2695970..2697454 - 1485 WP_000571552.1 cardiolipin synthase -
HF085_RS13315 (2697620) 2697620..2697913 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HF085_RS13320 (2697925) 2697925..2698134 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
HF085_RS13325 (2698262) 2698262..2698399 + 138 WP_000828354.1 Lmo0850 family protein -
HF085_RS13330 (2698662) 2698662..2699864 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
HF085_RS13335 (2700182) 2700182..2701252 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
HF085_RS13340 (2701267) 2701267..2702625 + 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T154232 WP_000581793.1 NZ_CP051479:2697925-2698134 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T154232 NZ_CP067413:c1062836-1062495 [Raoultella ornithinolytica]
ATGTGGGACATAGAAACGACGGACGCTTTCGATGAGTGGTTTGCGGCACAGACGGGTACGCTGCAGGAAGACATGCTGGC
CGCTATGGTGATTTTATCTGAGTATGGCCCACAGTTAGGCAGGCCGTTTGCAGATACCGTGAATGATTCTGCTTTTCCGA
ACATGAAAGAATTGCGCGTACAGCATCAAGGCAACCCAATCCGAGCCTTCTTTGCGTTTGATCCTTCCCGCCATGGCATC
GTGCTATGCGCCGGAGACAAAACGGGGTTGAACGAAAAGAAATTTTACAGAGACATGCTCAGGCTTGCCGATAATGAATA
CCGTAAGCACCTGAATAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT154232 WP_000138932.1 NZ_CP051479:2697620-2697913 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT154232 NZ_CP067413:c1062485-1062186 [Raoultella ornithinolytica]
ATGGCTACCCTTAAAGAACTGATGGCTAAGCAAAGTCCAGAAAGCCGGGAGCGTATTGCCGAAAAAGTGGAAGAACTTCG
CCAGACGATCGCTTTAAACATGCTTAGGGAAGAGCTGAATATTTCTCAAACGGAGCTGGCGGCGGCAATGGGCGTTAAGC
AGCCAACGGTCGCAAAAATGGAGCAGGCAGATAACGATCCCCGCCTGTCGACCCTGAAACGTTACGTCACCGCTCTGGGC
GGCGAACTCAGTATTGACGTGAAGCTCCCAACGGGCAAAAGGGTCGCATTTCACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References