Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1217249..1217726 | Replicon | chromosome |
| Accession | NZ_CP051479 | ||
| Organism | Staphylococcus aureus strain NGA76 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | HF085_RS06145 | Protein ID | WP_000052076.1 |
| Coordinates | 1217538..1217726 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | HF085_RS06140 | Protein ID | WP_001059690.1 |
| Coordinates | 1217249..1217509 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HF085_RS06105 (1212644) | 1212644..1213360 | - | 717 | WP_000150021.1 | type I 3-dehydroquinate dehydratase | - |
| HF085_RS06110 (1213508) | 1213508..1213930 | + | 423 | WP_000974447.1 | organic hydroperoxide resistance protein | - |
| HF085_RS06115 (1214329) | 1214329..1214823 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| HF085_RS06120 (1214977) | 1214977..1215594 | + | 618 | WP_000255561.1 | LysE/ArgO family amino acid transporter | - |
| HF085_RS06125 (1215667) | 1215667..1216248 | - | 582 | WP_001140690.1 | histidine phosphatase family protein | - |
| HF085_RS06130 (1216473) | 1216473..1216709 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| HF085_RS06135 (1216706) | 1216706..1216909 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| HF085_RS06140 (1217249) | 1217249..1217509 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| HF085_RS06145 (1217538) | 1217538..1217726 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| HF085_RS06150 (1217914) | 1217914..1218483 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| HF085_RS06155 (1218571) | 1218571..1218855 | + | 285 | WP_001004395.1 | hypothetical protein | - |
| HF085_RS06160 (1218917) | 1218917..1219135 | + | 219 | WP_000005889.1 | hypothetical protein | - |
| HF085_RS06165 (1219630) | 1219630..1219830 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| HF085_RS06170 (1220187) | 1220187..1220873 | - | 687 | WP_001641381.1 | thermonuclease family protein | - |
| HF085_RS06175 (1221214) | 1221214..1221723 | - | 510 | WP_000824480.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 1153392..1235724 | 82332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T154223 WP_000052076.1 NZ_CP051479:1217538-1217726 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T154223 NZ_CP067412:c766826-766473 [Pseudomonas sp. HS6]
ATGAGAGTGATCACAAAAGCGGCGGTTGCGCGGGCTATCGAAACCCATAGCCAGTGGAGAGATCCTCTCACCTTATGGTT
AACCATCTTCGACAGGGCATCCCTGCGGTTCGAGTCTTTTGAGAAGCTTCGCAAAGACTGGGCTATGGCATCAGGCTGGA
ACGTTGATCGAATCCCTCACTCGAAGCTGAGGATTACGAGTAAAAAAGGACCTCTTGATATTTATGTTTTCGATATCAAG
AAAAATGAGTGCCGGGTCATTACATGGATTAACCCCAAGATCGGCACCATTTATATAAAGGAGATTTTGCCCCATGCCGG
ATATGACAAGTGGTGGAAGGGTGATGTTAAGTAG
ATGAGAGTGATCACAAAAGCGGCGGTTGCGCGGGCTATCGAAACCCATAGCCAGTGGAGAGATCCTCTCACCTTATGGTT
AACCATCTTCGACAGGGCATCCCTGCGGTTCGAGTCTTTTGAGAAGCTTCGCAAAGACTGGGCTATGGCATCAGGCTGGA
ACGTTGATCGAATCCCTCACTCGAAGCTGAGGATTACGAGTAAAAAAGGACCTCTTGATATTTATGTTTTCGATATCAAG
AAAAATGAGTGCCGGGTCATTACATGGATTAACCCCAAGATCGGCACCATTTATATAAAGGAGATTTTGCCCCATGCCGG
ATATGACAAGTGGTGGAAGGGTGATGTTAAGTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT154223 WP_001059690.1 NZ_CP051479:1217249-1217509 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT154223 NZ_CP067412:c766420-765947 [Pseudomonas sp. HS6]
ATGAAGCGCAATAAGGTCGAAGCCTCTGGACTGGATTCCTTCATAGCTGACATTTCACCCATGCTTGATGGTTTGGGCGA
TCAGATCGCTACGTTGTCCAAATTGCTGTCTGCCTGCCACGATCCGATAAAGAGCGATGCTGACTTGCAAGGGCGAATGG
CGTTAATCGATGAGCTCTACTCTCATGCTGACAGTGAAGATCATGCAGCGGCACGATTTGCAGAGTTGGTGGCTGATCGT
GTGTATGAGTACGAGACTGAAACCGTTTTGATTCCTTACTCCACTCAATCGGAAGCGCTTGCGTTTCTGATCTCCGAAAG
AGGGGTAAAGCAAAAGGATTTGTCCGGGATTGCAACTCAGAGTGCCGTTTCAGAGATATTGAATAACAAGCGCAAGATGA
CCGTCGCTCAGATCAAAGGCTTTGCTGAGTTCTTCAAGGTTCCGGTCGAGTTTTTCATGCACGGTGTCGTTTGA
ATGAAGCGCAATAAGGTCGAAGCCTCTGGACTGGATTCCTTCATAGCTGACATTTCACCCATGCTTGATGGTTTGGGCGA
TCAGATCGCTACGTTGTCCAAATTGCTGTCTGCCTGCCACGATCCGATAAAGAGCGATGCTGACTTGCAAGGGCGAATGG
CGTTAATCGATGAGCTCTACTCTCATGCTGACAGTGAAGATCATGCAGCGGCACGATTTGCAGAGTTGGTGGCTGATCGT
GTGTATGAGTACGAGACTGAAACCGTTTTGATTCCTTACTCCACTCAATCGGAAGCGCTTGCGTTTCTGATCTCCGAAAG
AGGGGTAAAGCAAAAGGATTTGTCCGGGATTGCAACTCAGAGTGCCGTTTCAGAGATATTGAATAACAAGCGCAAGATGA
CCGTCGCTCAGATCAAAGGCTTTGCTGAGTTCTTCAAGGTTCCGGTCGAGTTTTTCATGCACGGTGTCGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |