Detailed information of TA system TA154216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1613712..1614391
• Replicon: chromosome
• Accession: NZ_CP051474
• Organism: Acinetobacter baumannii strain VB2107

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HBN37_RS07900
• Protein ID: WP_000838146.1
• Coordinates: 1613712..1613894 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HBN37_RS07905
• Protein ID: WP_000966688.1
• Coordinates: 1613987..1614391 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBN37_RS07865	1609087..1609491	+	405	WP_000248222.1	hypothetical protein	-
HBN37_RS07870	1609463..1609831	+	369	WP_000539746.1	hypothetical protein	-
HBN37_RS07875	1609833..1610231	+	399	WP_000178914.1	hypothetical protein	-
HBN37_RS07880	1610300..1610653	+	354	WP_000064602.1	hypothetical protein	-
HBN37_RS07885	1610653..1611831	+	1179	WP_169063658.1	phage tail protein	-
HBN37_RS07890	1611884..1612801	+	918	WP_000094278.1	hypothetical protein	-
HBN37_RS07895	1612871..1613386	+	516	WP_003115745.1	hypothetical protein	-
HBN37_RS07900	1613712..1613894	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HBN37_RS07905	1613987..1614391	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HBN37_RS07910	1614490..1614810	+	321	WP_000721573.1	hypothetical protein	-
HBN37_RS07915	1614913..1615656	+	744	WP_000599539.1	hypothetical protein	-
HBN37_RS07920	1615670..1616050	-	381	WP_000083174.1	hypothetical protein	-
HBN37_RS07925	1616193..1617140	+	948	WP_000096292.1	hypothetical protein	-
HBN37_RS07930	1617470..1617817	+	348	WP_099973747.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1589345..1634596	45251

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T154216 WP_000838146.1 NZ_CP051474:1613712-1613894 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T154216 NZ_CP067399:c4082963-4082676 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT154216 WP_000966688.1 NZ_CP051474:1613987-1614391 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT154216 NZ_CP067399:c4082689-4082387 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6