154212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1413558..1414108 Replicon chromosome
Accession NZ_CP051468
Organism Cereibacter sphaeroides strain CH10

Toxin (Protein)


Gene name brnT Uniprot ID Q3J2R5
Locus tag HGN32_RS06875 Protein ID WP_002719915.1
Coordinates 1413860..1414108 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q3J2R4
Locus tag HGN32_RS06870 Protein ID WP_011337726.1
Coordinates 1413558..1413863 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGN32_RS06850 1411172..1411465 - 294 WP_011337728.1 hypothetical protein -
HGN32_RS06855 1411593..1411733 + 141 WP_002719918.1 hypothetical protein -
HGN32_RS06860 1411849..1412661 + 813 WP_023003613.1 hypothetical protein -
HGN32_RS06865 1412757..1413029 - 273 WP_011337727.1 hypothetical protein -
HGN32_RS06870 1413558..1413863 - 306 WP_011337726.1 BrnA antitoxin family protein Antitoxin
HGN32_RS06875 1413860..1414108 - 249 WP_002719915.1 BrnT family toxin Toxin
HGN32_RS06880 1415361..1415594 - 234 WP_011337724.1 tail protein X -
HGN32_RS06885 1415591..1416043 - 453 WP_002719913.1 hypothetical protein -
HGN32_RS06890 1416036..1416437 - 402 WP_011337723.1 hypothetical protein -
HGN32_RS06895 1416430..1416903 - 474 WP_017140200.1 hypothetical protein -
HGN32_RS06900 1416948..1417601 - 654 WP_011337721.1 head decoration protein -
HGN32_RS06905 1417616..1418404 - 789 WP_017140199.1 hypothetical protein -
HGN32_RS06910 1418401..1418694 - 294 WP_147175732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(23-97)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8950.40 Da        Isoelectric Point: 6.4624

>T154212 WP_002719915.1 NZ_CP051468:c1414108-1413860 [Cereibacter sphaeroides]
MLVIVWDEPKRRSNLAKHGLDFADLDEEFFLSSVVVPASAGRHMAIGRLEDGTIAVVFAVLGAEGVSIISMRPASRKERS
LL

Download         Length: 249 bp

>T154212 NZ_CP067399:2703557-2703664 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11061.61 Da        Isoelectric Point: 10.5767

>AT154212 WP_011337726.1 NZ_CP051468:c1413863-1413558 [Cereibacter sphaeroides]
MTKKRQLDTEETRIQRMIASDPDAPEATDAQLAQARPFTEAFPVLAEAMRRSAGGRPKLDAPKMSVSLRLDQDVVAHFKA
GGPGWQSRMNRALREAVGLSG

Download         Length: 306 bp

>AT154212 NZ_CP067399:c2703510-2703444 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q3J2R5

Antitoxin

Source ID Structure
AlphaFold DB Q3J2R4

References