Detailed information of TA system TA154211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 4454188..4455647
• Replicon: chromosome
• Accession: NZ_CP051467
• Organism: Stenotrophomonas maltophilia strain NEB515

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: HGN30_RS20800
• Protein ID: WP_032966429.1
• Coordinates: 4454787..4455647 (+)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: HGN30_RS20795
• Protein ID: WP_032966430.1
• Coordinates: 4454188..4454790 (+)
• Length: 201 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGN30_RS20765	4449882..4450145	-	264	WP_005412242.1	cell division protein FtsL	-
HGN30_RS20770	4450142..4451110	-	969	WP_005412241.1	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	-
HGN30_RS20775	4451125..4451571	-	447	WP_004143635.1	division/cell wall cluster transcriptional repressor MraZ	-
HGN30_RS20780	4451895..4452647	+	753	WP_032967109.1	NRDE family protein	-
HGN30_RS20785	4452965..4453444	+	480	WP_005412238.1	DM13 domain-containing protein	-
HGN30_RS20795	4454188..4454790	+	603	WP_032966430.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
HGN30_RS20800	4454787..4455647	+	861	WP_032966429.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HGN30_RS20805	4455801..4456619	-	819	WP_005412235.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
HGN30_RS20810	4456701..4458422	+	1722	WP_032966428.1	penicillin-binding protein activator	-
HGN30_RS20815	4458412..4458780	+	369	WP_024957270.1	YraN family protein	-
HGN30_RS20820	4458891..4459508	+	618	WP_005412232.1	metal-dependent hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (40-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (12-53)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 32166.74 Da
• Isoelectric Point: 6.2999

>T154211 WP_032966429.1 NZ_CP051467:4454787-4455647 [Stenotrophomonas maltophilia]
VTHSPPLPQRVASIRQRLLDLARSRGEDFQFVLDRFAVERLLYRLSASRYRDQFLLKGAMLFAVWFDAPHRPTRDADFLR
FGSADPDHLLHIARSLCAIPDDDGLCFDPGSIAIEATREEAEYEGLRIRLTAHLGRSRCHVQWDVGFGDAVTPPPPEIAY
PVMLDGFPLPCLHVYPRETVFAEKLEAIAALGIANSRMKDFFDLLALVREDAMDRPHLVAAIGATFDRRGTPAPPPLPYG
LTQSFAADTQKQTQWRAFLRRNRLIAPDLSSVIADYLDTLDTTVQS

Nucleotide

• Length: 861 bp

>T154211 NZ_CP067399:2703022-2703129 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 201 a.a.
• Molecular weight: 22331.07 Da
• Isoelectric Point: 11.2557

>AT154211 WP_032966430.1 NZ_CP051467:4454188-4454790 [Stenotrophomonas maltophilia]
MGNAEANARKLLRRAGTLRARELVTAGIARAQLTRLVEAGALIRLSRGVYALAERNSDDTDDGLRIIAERLPHPRLCLLS
ALRLHGLTTQAPFERWVSIGNSDRVPRIDWPPLRVVRMSAKTLNAGLEERRVGKRLIYVSNVAKTVVDCFKFRNLVGLDV
AIEALRDALHSRATTPDALMEYARICRVARLMRPYLDALA

Nucleotide

• Length: 603 bp

>AT154211 NZ_CP067399:c2702975-2702909 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT