Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 259658..261241 Replicon chromosome
Accession NZ_CP051467
Organism Stenotrophomonas maltophilia strain NEB515

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HGN30_RS01220 Protein ID WP_005411845.1
Coordinates 259919..261241 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HGN30_RS01215 Protein ID WP_005407534.1
Coordinates 259658..259915 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGN30_RS01205 255003..255638 - 636 WP_005407536.1 hypothetical protein -
HGN30_RS01210 255810..259496 + 3687 WP_005411846.1 indolepyruvate ferredoxin oxidoreductase family protein -
HGN30_RS01215 259658..259915 + 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
HGN30_RS01220 259919..261241 + 1323 WP_005411845.1 type II toxin-antitoxin system HipA family toxin Toxin
HGN30_RS01225 261242..261856 - 615 WP_005411844.1 DUF938 domain-containing protein -
HGN30_RS01230 262555..264186 + 1632 WP_005407531.1 TldD/PmbA family protein -
HGN30_RS01235 264217..265851 + 1635 WP_005407530.1 TldD/PmbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(152-400)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.08 Da        Isoelectric Point: 7.1219

>T154210 WP_005411845.1 NZ_CP051467:259919-261241 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNRSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

>T154210 NZ_CP067399:c2490060-2489884 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT154210 WP_005407534.1 NZ_CP051467:259658-259915 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp

>AT154210 NZ_CP067399:c2489838-2489422 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References