Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1357182..1358098 Replicon chromosome
Accession NZ_CP051464
Organism Bacillus mojavensis strain UCMB5075

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6H2JPL5
Locus tag HC660_RS07075 Protein ID WP_010333924.1
Coordinates 1357352..1358098 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6H2JPH3
Locus tag HC660_RS07070 Protein ID WP_010333922.1
Coordinates 1357182..1357352 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC660_RS07035 1354044..1354373 + 330 WP_168747516.1 XkdW family protein -
HC660_RS07040 1354370..1354534 + 165 WP_168747517.1 XkdX family protein -
HC660_RS07045 1354578..1355417 + 840 WP_168747518.1 phage portal protein -
HC660_RS07050 1355473..1355742 + 270 WP_168747520.1 hemolysin XhlA family protein -
HC660_RS07055 1355754..1356017 + 264 WP_010333919.1 phage holin -
HC660_RS07060 1356030..1356923 + 894 WP_168747522.1 N-acetylmuramoyl-L-alanine amidase -
HC660_RS07065 1356960..1357097 - 138 WP_128568473.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
HC660_RS07070 1357182..1357352 - 171 WP_010333922.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
HC660_RS07075 1357352..1358098 - 747 WP_010333924.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
HC660_RS07080 1358208..1359209 - 1002 WP_010333925.1 inorganic phosphate transporter family protein -
HC660_RS07085 1359222..1359839 - 618 WP_010333926.1 DUF47 domain-containing protein -
HC660_RS07090 1360116..1361432 - 1317 WP_168747524.1 serine/threonine exchanger -
HC660_RS07095 1361827..1362777 + 951 WP_168747526.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29153.57 Da        Isoelectric Point: 4.5470

>T154190 WP_010333924.1 NZ_CP051464:c1358098-1357352 [Bacillus mojavensis]
MLLFFQIMVWCTMAALGFYVYATWRFEAKVKEKMSAIRKTWYLLFVFGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAQGIDKLLKTYADKMNLTASL
CHYSTQPDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T154190 NZ_CP067397:c4179187-4178876 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6550.57 Da        Isoelectric Point: 10.7601

>AT154190 WP_010333922.1 NZ_CP051464:c1357352-1357182 [Bacillus mojavensis]
MENAFQNGCHPQAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT154190 NZ_CP067397:c4178879-4178433 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2JPL5

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2JPH3

References