Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 514142..514779 | Replicon | chromosome |
Accession | NZ_CP051463 | ||
Organism | Bacillus velezensis strain UCMB5140 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | HC661_RS02620 | Protein ID | WP_003156187.1 |
Coordinates | 514429..514779 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | I2HMS5 |
Locus tag | HC661_RS02615 | Protein ID | WP_003156188.1 |
Coordinates | 514142..514423 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HC661_RS02595 | 510507..511106 | - | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
HC661_RS02600 | 511199..511564 | + | 366 | WP_015416872.1 | holo-ACP synthase | - |
HC661_RS02605 | 511729..512736 | + | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
HC661_RS02610 | 512853..514022 | + | 1170 | WP_015416873.1 | alanine racemase | - |
HC661_RS02615 | 514142..514423 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
HC661_RS02620 | 514429..514779 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
HC661_RS02625 | 514897..515718 | + | 822 | WP_015416874.1 | STAS domain-containing protein | - |
HC661_RS02630 | 515723..516088 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
HC661_RS02635 | 516091..516492 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
HC661_RS02640 | 516504..517511 | + | 1008 | WP_015416875.1 | PP2C family protein-serine/threonine phosphatase | - |
HC661_RS02645 | 517575..517904 | + | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
HC661_RS02650 | 517901..518383 | + | 483 | WP_003156173.1 | anti-sigma B factor RsbW | - |
HC661_RS02655 | 518349..519137 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
HC661_RS02660 | 519137..519739 | + | 603 | WP_003156170.1 | SpoIIE family protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T154187 WP_003156187.1 NZ_CP051463:514429-514779 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T154187 NZ_CP067397:c3618750-3618475 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT154187 WP_003156188.1 NZ_CP051463:514142-514423 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT154187 NZ_CP067397:c3619013-3618753 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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