Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE(toxin)
Location 2697119..2697691 Replicon chromosome
Accession NZ_CP051461
Organism Polaromonas vacuolata strain KCTC 22033

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HC248_RS12290 Protein ID WP_168922727.1
Coordinates 2697407..2697691 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HC248_RS12285 Protein ID WP_168922726.1
Coordinates 2697119..2697403 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC248_RS12270 2692387..2692932 - 546 WP_202882383.1 DUF1415 domain-containing protein -
HC248_RS12275 2692935..2694596 - 1662 WP_168922724.1 energy-dependent translational throttle protein EttA -
HC248_RS12280 2694904..2696763 + 1860 WP_168922725.1 DEAD/DEAH box helicase -
HC248_RS12285 2697119..2697403 + 285 WP_168922726.1 hypothetical protein Antitoxin
HC248_RS12290 2697407..2697691 + 285 WP_168922727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC248_RS12295 2697751..2698521 - 771 WP_168922728.1 FadR family transcriptional regulator -
HC248_RS12300 2698536..2698916 - 381 WP_168922729.1 hypothetical protein -
HC248_RS12305 2699042..2699809 - 768 WP_168922730.1 SDR family oxidoreductase -
HC248_RS12310 2699812..2700882 - 1071 WP_168922731.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
HC248_RS12315 2700901..2701755 - 855 WP_168922732.1 carbohydrate ABC transporter permease -
HC248_RS12320 2701752..2702624 - 873 WP_168922733.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10704.42 Da        Isoelectric Point: 10.8407

>T154186 WP_168922727.1 NZ_CP051461:2697407-2697691 [Polaromonas vacuolata]
VELVWTRPAQADRKTIREFIATSNPSAALKIDKLLSDRSTSLINHPGLGRLGRLQGTRELVVHNNYILIYDVVNDLIRVL
RVLHAARQWPPIKD

Download         Length: 285 bp

>T154186 NZ_CP067397:c3145203-3144790 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10733.89 Da        Isoelectric Point: 5.1409

>AT154186 WP_168922726.1 NZ_CP051461:2697119-2697403 [Polaromonas vacuolata]
MNQATFTFRVDEGLKDEFSIAAKSRDRTGAQLLRDYMRDFVRQQQEDSEHDAFIRREVQIGLNAANAGDVVSAQEIESQA
AQWRAQMQRKLSGV

Download         Length: 285 bp

>AT154186 NZ_CP067397:c3145450-3145184 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References