Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2498887..2499581 Replicon chromosome
Accession NZ_CP051461
Organism Polaromonas vacuolata strain KCTC 22033

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag HC248_RS11380 Protein ID WP_168922576.1
Coordinates 2499219..2499581 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HC248_RS11375 Protein ID WP_168922575.1
Coordinates 2498887..2499222 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC248_RS11360 2495921..2497000 + 1080 WP_168922572.1 carotenoid 1,2-hydratase -
HC248_RS11365 2497184..2497465 + 282 WP_168922573.1 helix-turn-helix domain-containing protein -
HC248_RS11370 2497465..2498841 + 1377 WP_168922574.1 type II toxin-antitoxin system HipA family toxin -
HC248_RS11375 2498887..2499222 - 336 WP_168922575.1 helix-turn-helix domain-containing protein Antitoxin
HC248_RS11380 2499219..2499581 - 363 WP_168922576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC248_RS11385 2499709..2500191 - 483 WP_168922577.1 RES family NAD+ phosphorylase -
HC248_RS11390 2500188..2500712 - 525 WP_168922578.1 DUF2384 domain-containing protein -
HC248_RS11395 2500883..2502484 - 1602 WP_168922579.1 DHA2 family efflux MFS transporter permease subunit -
HC248_RS11400 2502581..2503933 - 1353 WP_168922580.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13315.52 Da        Isoelectric Point: 9.4244

>T154185 WP_168922576.1 NZ_CP051461:c2499581-2499219 [Polaromonas vacuolata]
MLTNEKPLRWIGSSYKDLMALPADVRSFFGFALSLAQASDKHDSAKVLKGFGGAGVLEVVDSDVGGTYRAVYSVKFFEAV
FVLHCFQKKSKCGIATPKEDMDIIYARLKVAETFIKELRK

Download         Length: 363 bp

>T154185 NZ_CP067397:c3134336-3133938 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12328.52 Da        Isoelectric Point: 9.1384

>AT154185 WP_168922575.1 NZ_CP051461:c2499222-2498887 [Polaromonas vacuolata]
MKTKIIDGVEVHIGSGNIFADLELADADKLKIKTGLVIEIRKALRNLDLTQQDAAKRMGITQPKVSDMMRGDLSNLSERK
LMDCLTRLGFDIEISVRPAKTLIGHLMLSTH

Download         Length: 336 bp

>AT154185 NZ_CP067397:c3134563-3134336 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References