Detailed information of TA system TA154184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1177797..1178467
• Replicon: chromosome
• Accession: NZ_CP051461
• Organism: Polaromonas vacuolata strain KCTC 22033

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HC248_RS05480
• Protein ID: WP_168921626.1
• Coordinates: 1177797..1178216 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HC248_RS05485
• Protein ID: WP_168921627.1
• Coordinates: 1178213..1178467 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC248_RS05465	1172832..1173386	+	555	WP_168921623.1	flavodoxin family protein	-
HC248_RS05470	1173405..1174163	-	759	WP_168921624.1	sulfurtransferase	-
HC248_RS05475	1174244..1177774	+	3531	WP_168921625.1	DNA polymerase III subunit alpha	-
HC248_RS05480	1177797..1178216	-	420	WP_168921626.1	type II toxin-antitoxin system VapC family toxin	Toxin
HC248_RS05485	1178213..1178467	-	255	WP_168921627.1	plasmid stabilization protein	Antitoxin
HC248_RS05490	1178541..1178708	+	168	WP_168921628.1	hypothetical protein	-
HC248_RS05495	1178769..1179800	-	1032	WP_168921629.1	cell envelope integrity protein TolA	-
HC248_RS05500	1179813..1180253	-	441	WP_168921630.1	biopolymer transporter ExbD	-
HC248_RS05505	1180267..1180959	-	693	WP_168921631.1	protein TolQ	-
HC248_RS05510	1180974..1181444	-	471	WP_168921632.1	YbgC/FadM family acyl-CoA thioesterase	-
HC248_RS05515	1181437..1182657	-	1221	WP_168921633.1	pyridoxal phosphate-dependent aminotransferase	-
HC248_RS05520	1182700..1183224	-	525	WP_168921634.1	transcription antitermination factor NusB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14927.38 Da
• Isoelectric Point: 9.5030

>T154184 WP_168921626.1 NZ_CP051461:c1178216-1177797 [Polaromonas vacuolata]
MIVLDTNVVSEAMKPEPHPAVRAWLNAQAAPTLYLSSVTLAELLFGIAALPSGKRKDMLAKALDALLGLFRDRILAFDTD
AARRYAELAVTARTVGRGFPTPDGYIAAIAASRGFMIASRDTAPYLAARLTVINPWDAV

Nucleotide

• Length: 420 bp

>T154184 NZ_CP067397:2985691-2986218 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9083.44 Da
• Isoelectric Point: 4.5535

>AT154184 WP_168921627.1 NZ_CP051461:c1178467-1178213 [Polaromonas vacuolata]
MAILTIRNLPDEVHRALRIQAALNGLSTEAEVRRIIALAVKPEARLCLGDALAALSREIGLTNADFDVFDSVRDTAPAEP
LGFE

Nucleotide

• Length: 255 bp

>AT154184 NZ_CP067397:2985404-2985694 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA