Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 883962..885519 Replicon chromosome
Accession NZ_CP051461
Organism Polaromonas vacuolata strain KCTC 22033

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag HC248_RS04165 Protein ID WP_168921406.1
Coordinates 884212..885519 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag HC248_RS04160 Protein ID WP_168921405.1
Coordinates 883962..884222 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC248_RS04135 880086..880727 + 642 WP_168921401.1 OmpA family protein -
HC248_RS04140 880797..881510 + 714 WP_168921402.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
HC248_RS04145 881534..882199 + 666 WP_168921403.1 HAD-IA family hydrolase -
HC248_RS04155 883131..883748 + 618 WP_168921404.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
HC248_RS04160 883962..884222 + 261 WP_168921405.1 helix-turn-helix transcriptional regulator Antitoxin
HC248_RS04165 884212..885519 + 1308 WP_168921406.1 type II toxin-antitoxin system HipA family toxin Toxin
HC248_RS04170 885527..885784 - 258 WP_168921407.1 hypothetical protein -
HC248_RS04175 886028..887077 - 1050 Protein_814 Fic family protein -
HC248_RS04180 887364..889424 - 2061 WP_202882447.1 AAA family ATPase -
HC248_RS04185 890163..890426 - 264 WP_168921408.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47888.96 Da        Isoelectric Point: 7.4190

>T154183 WP_168921406.1 NZ_CP051461:884212-885519 [Polaromonas vacuolata]
MAHELEVWLFADRVGTLALVDGRLNFCYASAWLSQPAAVALSVSLPLQTQPFDDRRTRPFFAGLLPEGQMRRLIAQQFQV
SSQNDFALLDHIGGECAGAVTFIAQGQALAVPACNNDVQWLSDDEVVAILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGSRMGLPKNGTPSSHILKPAIHAVEDSVINEGFCLALAEAMQLKPAKSKVHFVLDRSFLLVERYDRLIDAQGYRHRLHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFELLRRVTRPSAPQVLRLLDCMIFNALIGNHDAHAKNFSLLYLGEKSGKTPVLS
PFYDTLSTAVYPTLSQKMAMKIGSKYKFSEVRVGHWEQFAESAGLTKSQAKRRILALAKSLPATARKLQSDPGYSFSGNA
VVEKINVLIEQRCALTSRRLTNPAAENDATAEPSD

Download         Length: 1308 bp

>T154183 NZ_CP067397:c1968813-1968710 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8902.19 Da        Isoelectric Point: 5.7440

>AT154183 WP_168921405.1 NZ_CP051461:883962-884222 [Polaromonas vacuolata]
MTSIRSSQQLGGALRTARKQLGLTQPQLALAAGVGVRFIVDLEAGKPTVRLENVLLVIDALGGEIQLSGLPTIAADDQRE
GGDHGA

Download         Length: 261 bp

>AT154183 NZ_CP067397:1968708-1968853 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References