Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 282695..283344 Replicon chromosome
Accession NZ_CP051461
Organism Polaromonas vacuolata strain KCTC 22033

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HC248_RS01440 Protein ID WP_202882445.1
Coordinates 282937..283344 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HC248_RS01435 Protein ID WP_168920945.1
Coordinates 282695..282928 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC248_RS01405 278238..279368 + 1131 WP_168920939.1 UDP-N-acetyl glucosamine 2-epimerase -
HC248_RS01410 279381..280625 + 1245 WP_168920940.1 glycosyltransferase family 4 protein -
HC248_RS01415 280622..281572 + 951 WP_168920941.1 SDR family oxidoreductase -
HC248_RS01420 281623..281871 + 249 WP_168920942.1 hypothetical protein -
HC248_RS01425 281950..282360 + 411 WP_168920943.1 hypothetical protein -
HC248_RS01430 282443..282670 + 228 WP_168920944.1 hypothetical protein -
HC248_RS01435 282695..282928 + 234 WP_168920945.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HC248_RS01440 282937..283344 + 408 WP_202882445.1 type II toxin-antitoxin system VapC family toxin Toxin
HC248_RS01445 283452..284012 + 561 WP_168920946.1 sugar transferase -
HC248_RS01450 284224..285087 + 864 WP_168920947.1 hypothetical protein -
HC248_RS01455 285447..287228 + 1782 WP_168920948.1 exodeoxyribonuclease VII large subunit -
HC248_RS01460 287357..287632 + 276 WP_168923608.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14586.71 Da        Isoelectric Point: 5.7040

>T154181 WP_202882445.1 NZ_CP051461:282937-283344 [Polaromonas vacuolata]
MLDTNICIYVINVRPPAVLARFRLESLGSIGVSSVTAAELTFGVAKNGSARNRTALEMFLTAVEVLPFDASAIWHYGDLR
AALERRGQPIGALDTMIAAHALACNAILVSNNTREFERVPGLRLENWASGTLDSD

Download         Length: 408 bp

>T154181 NZ_CP067397:c528252-528034 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8725.89 Da        Isoelectric Point: 5.7834

>AT154181 WP_168920945.1 NZ_CP051461:282695-282928 [Polaromonas vacuolata]
MDTARLFQSGRSQAVRLPKEYRFEGDKVVVRHFGNGVLLLPVNEPWAILDAALNSFEPGFQISRDQPEVQVRQEIAS

Download         Length: 234 bp

>AT154181 NZ_CP067397:c528654-528280 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References