Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 4928352..4929940 | Replicon | chromosome |
| Accession | NZ_CP051460 | ||
| Organism | Dickeya solani strain IFB0421 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A2K8W078 |
| Locus tag | HAT92_RS21465 | Protein ID | WP_022635525.1 |
| Coordinates | 4928621..4929940 (+) | Length | 440 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A2K8W0B1 |
| Locus tag | HAT92_RS21460 | Protein ID | WP_022635524.1 |
| Coordinates | 4928352..4928621 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HAT92_RS21435 | 4923670..4924281 | - | 612 | WP_022635519.1 | NAD(P)-dependent oxidoreductase | - |
| HAT92_RS21440 | 4924423..4924809 | + | 387 | WP_022635520.1 | helix-turn-helix transcriptional regulator | - |
| HAT92_RS21445 | 4924908..4925993 | - | 1086 | WP_022635521.1 | 4-hydroxyphenylpyruvate dioxygenase | - |
| HAT92_RS21450 | 4926308..4927081 | + | 774 | WP_022635522.1 | MBL fold metallo-hydrolase | - |
| HAT92_RS21455 | 4927125..4928081 | + | 957 | WP_026595316.1 | helix-turn-helix domain-containing protein | - |
| HAT92_RS21460 | 4928352..4928621 | + | 270 | WP_022635524.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HAT92_RS21465 | 4928621..4929940 | + | 1320 | WP_022635525.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HAT92_RS21470 | 4930012..4931375 | - | 1364 | Protein_4188 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE | - |
| HAT92_RS21475 | 4931491..4933122 | - | 1632 | WP_022635527.1 | membrane protein insertase YidC | - |
| HAT92_RS21480 | 4933125..4933382 | - | 258 | WP_071598660.1 | membrane protein insertion efficiency factor YidD | - |
| HAT92_RS21485 | 4933346..4933705 | - | 360 | WP_022635528.1 | ribonuclease P protein component | - |
| HAT92_RS21490 | 4933724..4933864 | - | 141 | WP_004093983.1 | 50S ribosomal protein L34 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 440 a.a. Molecular weight: 49161.32 Da Isoelectric Point: 6.6616
>T154179 WP_022635525.1 NZ_CP051460:4928621-4929940 [Dickeya solani]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE
Download Length: 1320 bp
>T154179 NZ_CP067394:c2878862-2878467 [Cryobacterium sp. SO1]
GTGATCGTCTACATCGATACCTCCGCCGTCCGGAAACTTATCTTGGAGGAACCCGAGTCGACCGCGCTCGCCCAGTACCT
CGACGAGTTGTCGGCCAGGGACGGTGTAACCCTGGTTTCGGCTGCACTCCTGGAGACTGAGCTGCGTCGATTGGCGGATC
GCACTGCGGTGTCGCAGCTCGCGGTCACCGACGTGCTGAGACGGATCACTCTTGTGGACATCGAACGCGGGTCGTTTCGT
GAAGCGGGTCTCATCCTGCCCGGGTCGTCGCTTCGGAGCGTGGATGCACTCCATATCGCGGTTGCCGTGAGGGTGGCGAC
CGATGAATTCATCACGTATGACCGTCGTCAGGCTGAAGCTGCGCAATCGGCGGGCCTAACTCTCGTCCAGCCGTAA
GTGATCGTCTACATCGATACCTCCGCCGTCCGGAAACTTATCTTGGAGGAACCCGAGTCGACCGCGCTCGCCCAGTACCT
CGACGAGTTGTCGGCCAGGGACGGTGTAACCCTGGTTTCGGCTGCACTCCTGGAGACTGAGCTGCGTCGATTGGCGGATC
GCACTGCGGTGTCGCAGCTCGCGGTCACCGACGTGCTGAGACGGATCACTCTTGTGGACATCGAACGCGGGTCGTTTCGT
GAAGCGGGTCTCATCCTGCCCGGGTCGTCGCTTCGGAGCGTGGATGCACTCCATATCGCGGTTGCCGTGAGGGTGGCGAC
CGATGAATTCATCACGTATGACCGTCGTCAGGCTGAAGCTGCGCAATCGGCGGGCCTAACTCTCGTCCAGCCGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9950.26 Da Isoelectric Point: 10.0983
>AT154179 WP_022635524.1 NZ_CP051460:4928352-4928621 [Dickeya solani]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW
Download Length: 270 bp
>AT154179 NZ_CP067394:c2879126-2878875 [Cryobacterium sp. SO1]
ATGAAAACCATCCCGCATCGTGAACTCAGAAACAACAGTGCGGAGGTTCTTCGCTCGGTTCAATCTGGAGAGTCTTTCGA
GGTGACCAACAACGGCGAGGTTGTCGCACTGCTGACGCCGCCGACCTCCGCAGCCCTTCGGGGCATTCGGTTTCGCCCGC
AATTGTCACGAGGAGGGTTCTCCGAATTGACGCGACACTCGTCCCCCCAGGCTGTCGGCGGCGTTCTGGACGACCTCCGC
GAAGAGCGCTGA
ATGAAAACCATCCCGCATCGTGAACTCAGAAACAACAGTGCGGAGGTTCTTCGCTCGGTTCAATCTGGAGAGTCTTTCGA
GGTGACCAACAACGGCGAGGTTGTCGCACTGCTGACGCCGCCGACCTCCGCAGCCCTTCGGGGCATTCGGTTTCGCCCGC
AATTGTCACGAGGAGGGTTCTCCGAATTGACGCGACACTCGTCCCCCCAGGCTGTCGGCGGCGTTCTGGACGACCTCCGC
GAAGAGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K8W078 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K8W0B1 |