Detailed information of TA system TA154178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3779437..3781277
• Replicon: chromosome
• Accession: NZ_CP051460
• Organism: Dickeya solani strain IFB0421

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2K8VX87
• Locus tag: HAT92_RS16580
• Protein ID: WP_022634631.1
• Coordinates: 3779931..3781277 (-)
• Length: 449 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HAT92_RS16575
• Protein ID: WP_022634630.1
• Coordinates: 3779437..3779934 (-)
• Length: 166 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAT92_RS16550	3774754..3775593	-	840	WP_022634625.1	MurR/RpiR family transcriptional regulator	-
HAT92_RS16555	3775768..3777357	+	1590	WP_022634626.1	gamma-glutamyltransferase family protein	-
HAT92_RS16560	3777402..3777599	+	198	WP_022634627.1	oxalurate catabolism protein HpxX	-
HAT92_RS16565	3777596..3779008	+	1413	WP_022634628.1	AtzE family amidohydrolase	-
HAT92_RS16570	3779005..3779385	+	381	WP_022634629.1	oxalurate catabolism protein HpxZ	-
HAT92_RS16575	3779437..3779934	-	498	WP_022634630.1	helix-turn-helix domain-containing protein	Antitoxin
HAT92_RS16580	3779931..3781277	-	1347	WP_022634631.1	type II toxin-antitoxin system HipA family toxin	Toxin
HAT92_RS16585	3781550..3782497	-	948	WP_022634632.1	allantoinase PuuE	-
HAT92_RS16590	3782541..3783278	-	738	WP_022634633.1	allantoin racemase	-
HAT92_RS16595	3783275..3784018	-	744	WP_022634634.1	GntR family transcriptional regulator	-
HAT92_RS16600	3784171..3785655	+	1485	WP_022634635.1	NCS1 family nucleobase:cation symporter-1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (165-392)

Antitoxin

• Cro/C1-type helix-turn-helix domain (89-142)

Sequences

Toxin

Protein

• Length: 449 a.a.
• Molecular weight: 50541.28 Da
• Isoelectric Point: 4.9663

>T154178 WP_022634631.1 NZ_CP051460:c3781277-3779931 [Dickeya solani]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Nucleotide

• Length: 1347 bp

>T154178 NZ_CP067394:2863248-2863508 [Cryobacterium sp. SO1]
GTGAGTCGGACGATCGCCTTCGACCCGAATGGGTGGGAGGACTACGTTTACTGGCAGACCCAGGACCGCAAGACGCTCAA
GCGGATCAATCAGCTGATCACCGACACGCTGCGCGATCCGTTCGCGGGCATCGGCAAGCCTGAGCCCCTTCGGCACGTTC
TCTCCGGCGCTTGGTCACGCCGCATCGACGACACGAACCGCCTGGTCTACTACGTCACCGACGACCGCATCGTCATCCTG
CAAGCCCGCGAACACTACTGA

Antitoxin

Protein

• Length: 166 a.a.
• Molecular weight: 18174.98 Da
• Isoelectric Point: 10.6920

>AT154178 WP_022634630.1 NZ_CP051460:c3779934-3779437 [Dickeya solani]
MSQKRNNTTDVYAGADDVQETIRKLRQRVQERNVALEQMLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRR
MMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTLSEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILAT
APASR

Nucleotide

• Length: 498 bp

>AT154178 NZ_CP067394:2863000-2863251 [Cryobacterium sp. SO1]
ATGTCGGCGATCACCGCGACCGAAGCACGCAAGAGCCTGTTCGGACTCATCCAGCAGGTCAACGACGACCACACCGCTAT
CGAGGTCGTCTCCCGGCACGGAAACGCGGTCATCCTGTCAAAGGAGGACTACGACGCGTTGACCGAAACGGCCTTCCTGC
TGCGGAACCCTGCGAACGCGGAGCGGTTGCTCGCAGCGATCGAGCGAGTCCGGCGCGGCGAGTTCGAGCAGCACGACCTA
CTGGACGCGTGA

Structures

Toxin

• AlphaFold DB: A0A2K8VX87