Detailed information of TA system TA154167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1882222..1882775
• Replicon: chromosome
• Accession: NZ_CP051460
• Organism: Dickeya solani strain IFB0421

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HAT92_RS08365
• Protein ID: WP_022633101.1
• Coordinates: 1882461..1882775 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A2K8W593
• Locus tag: HAT92_RS08360
• Protein ID: WP_022633100.1
• Coordinates: 1882222..1882458 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAT92_RS08340	1877798..1879447	+	1650	WP_022633097.1	hypothetical protein	-
HAT92_RS08345	1879808..1880209	-	402	WP_023637748.1	hypothetical protein	-
HAT92_RS08350	1880273..1880566	-	294	WP_146053334.1	hypothetical protein	-
HAT92_RS08355	1880957..1881901	+	945	WP_022633099.1	DUF1738 domain-containing protein	-
HAT92_RS08360	1882222..1882458	+	237	WP_022633100.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HAT92_RS08365	1882461..1882775	+	315	WP_022633101.1	CcdB family protein	Toxin
HAT92_RS08370	1882772..1883029	-	258	WP_022633102.1	hypothetical protein	-
HAT92_RS08375	1883205..1884512	-	1308	WP_022633103.1	type II toxin-antitoxin system HipA family toxin	-
HAT92_RS08380	1884512..1884919	-	408	WP_071598628.1	helix-turn-helix transcriptional regulator	-
HAT92_RS08385	1885302..1886048	-	747	WP_022633104.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp	1873239..1921616	48377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11459.38 Da
• Isoelectric Point: 7.9859

>T154167 WP_022633101.1 NZ_CP051460:1882461-1882775 [Dickeya solani]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T154167 NZ_CP067391:833774-834184 [Klebsiella grimontii]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCATGGCGCGCGCAGTGGTTTTCACTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTAGTGTTCGACTGCG
TACGCAGCCAGCGGCGGATCCACGCCCGTCAGGGCGAAATAAAGCTGCTGATCGATTCGCGTCTGCGCTGGCAAAAGGCG
GAGTGGGAGATTATCGGTACGCCGTGGGTAATCAACAGCGGCATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGTAC
CCAGCATTTATGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGCGACCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGAGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9020.06 Da
• Isoelectric Point: 6.2206

>AT154167 WP_022633100.1 NZ_CP051460:1882222-1882458 [Dickeya solani]
MTAKQRNTQSVTMTVERALLVRAREAGINLSAILTTALDAELRHHEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT154167 NZ_CP067391:833527-833793 [Klebsiella grimontii]
ATGGACATTAACAATAAAGCCCGTATCCATTGGGCATGTCGTCGAGGTATGCGTGAACTCGATATATCCATCATGCCGTT
TTTCGAGCATGAGTACGATACGCTAAGCGATGGCGATAAGGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TCTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCTGAACTGCAGCGGATGGTAAAATTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K8W593