Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1767445..1768062 Replicon chromosome
Accession NZ_CP051460
Organism Dickeya solani strain IFB0421

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag HAT92_RS07860 Protein ID WP_012764944.1
Coordinates 1767883..1768062 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag HAT92_RS07855 Protein ID WP_022633005.1
Coordinates 1767445..1767855 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT92_RS07830 1762945..1763862 + 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -
HAT92_RS07835 1763859..1764881 + 1023 WP_022633001.1 iron ABC transporter permease -
HAT92_RS07840 1764874..1765923 + 1050 WP_022633002.1 iron ABC transporter permease -
HAT92_RS07845 1765935..1766780 + 846 WP_023637730.1 ABC transporter ATP-binding protein -
HAT92_RS07850 1766777..1767442 + 666 WP_022633004.1 RraA family protein -
HAT92_RS07855 1767445..1767855 - 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HAT92_RS07860 1767883..1768062 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
HAT92_RS07865 1768384..1768746 + 363 WP_071598627.1 hypothetical protein -
HAT92_RS07870 1769082..1770137 - 1056 WP_022633006.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T154166 WP_012764944.1 NZ_CP051460:c1768062-1767883 [Dickeya solani]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T154166 NZ_CP067391:42901-43242 [Klebsiella grimontii]
ATGTGGGATGTTGAAACAACGGAGGTTTTCGACAAGTGGTTTGAGGCGCAGATCGAAGCGCTTAAAGAGGATATGCTCGC
CGCTATGGTGATCTTATCCGAGTATGGCCCCCAACTCGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCTTTTTCGA
ATATGAAAGAGCTGCGCGTTCAGCATCGAGGTAGCCCGATCAGAGCTTTCTTTGTATTTGACCCTTCTCGTCGCGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT154166 WP_022633005.1 NZ_CP051460:c1767855-1767445 [Dickeya solani]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp

>AT154166 NZ_CP067391:43252-43551 [Klebsiella grimontii]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAAGAAATGCG
CCAGGCTATCGCATTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATTGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGTTATGTTGTAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References