Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 598163..598689 Replicon chromosome
Accession NZ_CP051460
Organism Dickeya solani strain IFB0421

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag HAT92_RS02790 Protein ID WP_022632051.1
Coordinates 598163..598468 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag HAT92_RS02795 Protein ID WP_022632052.1
Coordinates 598471..598689 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT92_RS02770 593385..593782 + 398 Protein_537 DUF3577 domain-containing protein -
HAT92_RS02775 593898..595169 + 1272 WP_022632048.1 hypothetical protein -
HAT92_RS02780 595173..595745 + 573 WP_022632049.1 hypothetical protein -
HAT92_RS02785 595733..597673 + 1941 WP_022632050.1 hypothetical protein -
HAT92_RS02790 598163..598468 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
HAT92_RS02795 598471..598689 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HAT92_RS02800 598748..599491 - 744 WP_022632053.1 hypothetical protein -
HAT92_RS02805 600394..600744 - 351 WP_013316250.1 hypothetical protein -
HAT92_RS02810 600867..601055 + 189 WP_033111580.1 hypothetical protein -
HAT92_RS02815 601195..602454 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
HAT92_RS02825 602852..603427 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592306..602631 10325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T154162 WP_022632051.1 NZ_CP051460:c598468-598163 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T154162 NZ_CP067373:56279-56761 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT154162 WP_022632052.1 NZ_CP051460:c598689-598471 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT154162 NZ_CP067373:56025-56291 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References