Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1767485..1768102 Replicon chromosome
Accession NZ_CP051458
Organism Dickeya solani strain IFB0231

Toxin (Protein)


Gene name hicA Uniprot ID C6CDL0
Locus tag HAT89_RS07850 Protein ID WP_012764944.1
Coordinates 1767923..1768102 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K8W4Y6
Locus tag HAT89_RS07845 Protein ID WP_022633005.1
Coordinates 1767485..1767895 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT89_RS07820 1762985..1763902 + 918 WP_023637727.1 iron-siderophore ABC transporter substrate-binding protein -
HAT89_RS07825 1763899..1764921 + 1023 WP_022633001.1 iron ABC transporter permease -
HAT89_RS07830 1764914..1765963 + 1050 WP_022633002.1 iron ABC transporter permease -
HAT89_RS07835 1765975..1766820 + 846 WP_023637730.1 ABC transporter ATP-binding protein -
HAT89_RS07840 1766817..1767482 + 666 WP_022633004.1 RraA family protein -
HAT89_RS07845 1767485..1767895 - 411 WP_022633005.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HAT89_RS07850 1767923..1768102 - 180 WP_012764944.1 type II toxin-antitoxin system HicA family toxin Toxin
HAT89_RS07855 1768424..1768786 + 363 WP_071598627.1 hypothetical protein -
HAT89_RS07860 1769122..1770177 - 1056 WP_022633006.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6530.61 Da        Isoelectric Point: 10.7838

>T154147 WP_012764944.1 NZ_CP051458:c1768102-1767923 [Dickeya solani]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T154147 NZ_CP067370:c5252365-5251982 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14499.48 Da        Isoelectric Point: 4.3391

>AT154147 WP_022633005.1 NZ_CP051458:c1767895-1767485 [Dickeya solani]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Download         Length: 411 bp

>AT154147 NZ_CP067370:c5252607-5252365 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4W9

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4Y6

References