154146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1684148..1684928 Replicon chromosome
Accession NZ_CP051458
Organism Dickeya solani strain IFB0231

Toxin (Protein)


Gene name dhiT Uniprot ID A0A2K8W4P2
Locus tag HAT89_RS07455 Protein ID WP_022632927.1
Coordinates 1684148..1684405 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID A0A2K8W4X0
Locus tag HAT89_RS07460 Protein ID WP_022632928.1
Coordinates 1684413..1684928 (+) Length 172 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT89_RS07445 1680908..1683058 - 2151 WP_022632925.1 formate dehydrogenase subunit alpha -
HAT89_RS07450 1683093..1683635 - 543 WP_022632926.1 4Fe-4S dicluster domain-containing protein -
HAT89_RS07455 1684148..1684405 + 258 WP_022632927.1 DUF4160 domain-containing protein Toxin
HAT89_RS07460 1684413..1684928 + 516 WP_022632928.1 DUF2442 domain-containing protein Antitoxin
HAT89_RS07465 1685007..1685504 - 498 WP_022632929.1 hydrogenase maturation peptidase HycI -
HAT89_RS07470 1685497..1685895 - 399 WP_022632930.1 formate hydrogenlyase maturation HycH family protein -
HAT89_RS07475 1685892..1686683 - 792 WP_022632931.1 NADH-quinone oxidoreductase subunit B family protein -
HAT89_RS07480 1686680..1687249 - 570 WP_022632932.1 hydrogenase 4 subunit H -
HAT89_RS07485 1687260..1688987 - 1728 WP_022632933.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(80-157)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10007.56 Da        Isoelectric Point: 8.1243

>T154146 WP_022632927.1 NZ_CP051458:1684148-1684405 [Dickeya solani]
MPEVDRLAGLIFHLYFYDDERHYLPHVHVCYGNHELIISIRTGTEIEGYLPNNKRKMALAHIRAHREQLLSMWERAVVGR
NPGKL

Download         Length: 258 bp

>T154146 NZ_CP067370:c4928933-4928016 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 172 a.a.        Molecular weight: 19099.82 Da        Isoelectric Point: 5.2747

>AT154146 WP_022632928.1 NZ_CP051458:1684413-1684928 [Dickeya solani]
MHKIVEVDVIGDFSLRLTYDDGLVCDINLYQYASSPVFSDVSLFIKFGLLPDGALEWLPDIKISASELRKKGEYVSHTLA
VRERHFADVISRAFYDAVIENRPEILQAALKIAVEKHGNSTVAKEAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
ELQLEDLQLEE

Download         Length: 516 bp

>AT154146 NZ_CP067370:c4929697-4928939 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W4P2

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W4X0

References