Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1222456..1223081 Replicon chromosome
Accession NZ_CP051458
Organism Dickeya solani strain IFB0231

Toxin (Protein)


Gene name Hha Uniprot ID A0A2K8W3K4
Locus tag HAT89_RS05570 Protein ID WP_022632574.1
Coordinates 1222456..1222659 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8W3I1
Locus tag HAT89_RS05575 Protein ID WP_022632575.1
Coordinates 1222713..1223081 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT89_RS05540 1218096..1218434 + 339 WP_002208627.1 P-II family nitrogen regulator -
HAT89_RS05545 1218477..1219769 + 1293 WP_022632570.1 ammonium transporter AmtB -
HAT89_RS05550 1219865..1220728 - 864 WP_022632571.1 acyl-CoA thioesterase II -
HAT89_RS05555 1220980..1221537 + 558 WP_022632572.1 YbaY family lipoprotein -
HAT89_RS05560 1221566..1221895 - 330 WP_022632573.1 MGMT family protein -
HAT89_RS05570 1222456..1222659 - 204 WP_022632574.1 hemolysin expression modulator Hha Toxin
HAT89_RS05575 1222713..1223081 - 369 WP_022632575.1 Hha toxicity modulator TomB Antitoxin
HAT89_RS05580 1223589..1223732 - 144 WP_022632576.1 type B 50S ribosomal protein L36 -
HAT89_RS05585 1223748..1223999 - 252 WP_022632577.1 type B 50S ribosomal protein L31 -
HAT89_RS05590 1224176..1227322 - 3147 WP_022632578.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.52 Da        Isoelectric Point: 8.8580

>T154145 WP_022632574.1 NZ_CP051458:c1222659-1222456 [Dickeya solani]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T154145 NZ_CP067370:c4767837-4767553 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14223.06 Da        Isoelectric Point: 5.1663

>AT154145 WP_022632575.1 NZ_CP051458:c1223081-1222713 [Dickeya solani]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT154145 NZ_CP067370:c4768069-4767827 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W3K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W3I1

References