Detailed information of TA system TA154144

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 734207..734885
• Replicon: chromosome
• Accession: NZ_CP051458
• Organism: Dickeya solani strain IFB0231

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HAT89_RS03450
• Protein ID: WP_023637601.1
• Coordinates: 734454..734885 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2K8QSU7
• Locus tag: HAT89_RS03445
• Protein ID: WP_023637600.1
• Coordinates: 734207..734473 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAT89_RS03425	730657..731307	+	651	WP_022632163.1	LysE family translocator	-
HAT89_RS03430	731378..731986	-	609	WP_022632164.1	HD domain-containing protein	-
HAT89_RS03435	732196..732846	+	651	WP_022632165.1	hemolysin III family protein	-
HAT89_RS03440	732920..733900	-	981	WP_022632166.1	tRNA-modifying protein YgfZ	-
HAT89_RS03445	734207..734473	+	267	WP_023637600.1	FAD assembly factor SdhE	Antitoxin
HAT89_RS03450	734454..734885	+	432	WP_023637601.1	protein YgfX	Toxin
HAT89_RS03455	734985..735503	-	519	WP_022632169.1	flavodoxin FldB	-
HAT89_RS03460	735632..736957	-	1326	WP_022632170.1	MHS family MFS transporter	-
HAT89_RS03465	737220..738119	+	900	WP_022632171.1	site-specific tyrosine recombinase XerD	-
HAT89_RS03470	738209..738916	+	708	WP_022632172.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16808.51 Da
• Isoelectric Point: 11.7737

>T154144 WP_023637601.1 NZ_CP051458:734454-734885 [Dickeya solani]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T154144 NZ_CP067370:c4675166-4674825 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.03 Da
• Isoelectric Point: 5.5535

>AT154144 WP_023637600.1 NZ_CP051458:734207-734473 [Dickeya solani]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT154144 NZ_CP067370:c4675528-4675187 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8QSU7