Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 598175..598701 Replicon chromosome
Accession NZ_CP051458
Organism Dickeya solani strain IFB0231

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag HAT89_RS02785 Protein ID WP_022632051.1
Coordinates 598175..598480 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag HAT89_RS02790 Protein ID WP_022632052.1
Coordinates 598483..598701 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT89_RS02765 593397..593794 + 398 Protein_536 DUF3577 domain-containing protein -
HAT89_RS02770 593910..595181 + 1272 WP_022632048.1 hypothetical protein -
HAT89_RS02775 595185..595757 + 573 WP_022632049.1 hypothetical protein -
HAT89_RS02780 595745..597685 + 1941 WP_022632050.1 hypothetical protein -
HAT89_RS02785 598175..598480 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
HAT89_RS02790 598483..598701 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HAT89_RS02795 598760..599503 - 744 WP_022632053.1 hypothetical protein -
HAT89_RS02800 600406..600756 - 351 WP_013316250.1 hypothetical protein -
HAT89_RS02805 600879..601067 + 189 WP_033111580.1 hypothetical protein -
HAT89_RS02810 601207..602466 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
HAT89_RS02820 602864..603439 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592318..602643 10325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T154143 WP_022632051.1 NZ_CP051458:c598480-598175 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T154143 NZ_CP067370:c4644694-4644161 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT154143 WP_022632052.1 NZ_CP051458:c598701-598483 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT154143 NZ_CP067370:c4644971-4644705 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References