Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 4916103..4917691 | Replicon | chromosome |
| Accession | NZ_CP051457 | ||
| Organism | Dickeya solani strain IFB0167 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A2K8W078 |
| Locus tag | HAT87_RS21370 | Protein ID | WP_022635525.1 |
| Coordinates | 4916372..4917691 (+) | Length | 440 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A2K8W0B1 |
| Locus tag | HAT87_RS21365 | Protein ID | WP_022635524.1 |
| Coordinates | 4916103..4916372 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HAT87_RS21340 | 4911421..4912032 | - | 612 | WP_022635519.1 | NAD(P)-dependent oxidoreductase | - |
| HAT87_RS21345 | 4912174..4912560 | + | 387 | WP_022635520.1 | helix-turn-helix transcriptional regulator | - |
| HAT87_RS21350 | 4912659..4913744 | - | 1086 | WP_022635521.1 | 4-hydroxyphenylpyruvate dioxygenase | - |
| HAT87_RS21355 | 4914059..4914832 | + | 774 | WP_022635522.1 | MBL fold metallo-hydrolase | - |
| HAT87_RS21360 | 4914876..4915832 | + | 957 | WP_026595316.1 | helix-turn-helix domain-containing protein | - |
| HAT87_RS21365 | 4916103..4916372 | + | 270 | WP_022635524.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HAT87_RS21370 | 4916372..4917691 | + | 1320 | WP_022635525.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HAT87_RS21375 | 4917763..4919127 | - | 1365 | WP_022635526.1 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE | - |
| HAT87_RS21380 | 4919243..4920874 | - | 1632 | WP_022635527.1 | membrane protein insertase YidC | - |
| HAT87_RS21385 | 4920877..4921134 | - | 258 | WP_071598660.1 | membrane protein insertion efficiency factor YidD | - |
| HAT87_RS21390 | 4921098..4921457 | - | 360 | WP_022635528.1 | ribonuclease P protein component | - |
| HAT87_RS21395 | 4921476..4921616 | - | 141 | WP_004093983.1 | 50S ribosomal protein L34 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 440 a.a. Molecular weight: 49161.32 Da Isoelectric Point: 6.6616
>T154141 WP_022635525.1 NZ_CP051457:4916372-4917691 [Dickeya solani]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE
Download Length: 1320 bp
>T154141 NZ_CP067370:3971027-3971245 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9950.26 Da Isoelectric Point: 10.0983
>AT154141 WP_022635524.1 NZ_CP051457:4916103-4916372 [Dickeya solani]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW
Download Length: 270 bp
>AT154141 NZ_CP067370:3970626-3971000 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K8W078 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K8W0B1 |