Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3767171..3769011 Replicon chromosome
Accession NZ_CP051457
Organism Dickeya solani strain IFB0167

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8VX87
Locus tag HAT87_RS16495 Protein ID WP_022634631.1
Coordinates 3767665..3769011 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HAT87_RS16490 Protein ID WP_022634630.1
Coordinates 3767171..3767668 (-) Length 166 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT87_RS16465 3762488..3763327 - 840 WP_022634625.1 MurR/RpiR family transcriptional regulator -
HAT87_RS16470 3763502..3765091 + 1590 WP_022634626.1 gamma-glutamyltransferase family protein -
HAT87_RS16475 3765136..3765333 + 198 WP_022634627.1 oxalurate catabolism protein HpxX -
HAT87_RS16480 3765330..3766742 + 1413 WP_022634628.1 AtzE family amidohydrolase -
HAT87_RS16485 3766739..3767119 + 381 WP_022634629.1 oxalurate catabolism protein HpxZ -
HAT87_RS16490 3767171..3767668 - 498 WP_022634630.1 helix-turn-helix domain-containing protein Antitoxin
HAT87_RS16495 3767665..3769011 - 1347 WP_022634631.1 type II toxin-antitoxin system HipA family toxin Toxin
HAT87_RS16500 3769284..3770231 - 948 WP_022634632.1 allantoinase PuuE -
HAT87_RS16505 3770275..3771012 - 738 WP_022634633.1 allantoin racemase -
HAT87_RS16510 3771009..3771752 - 744 WP_022634634.1 GntR family transcriptional regulator -
HAT87_RS16515 3771905..3773389 + 1485 WP_022634635.1 NCS1 family nucleobase:cation symporter-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(89-142)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50541.28 Da        Isoelectric Point: 4.9663

>T154140 WP_022634631.1 NZ_CP051457:c3769011-3767665 [Dickeya solani]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

>T154140 NZ_CP067370:c2693406-2692084 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGATGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 166 a.a.        Molecular weight: 18174.98 Da        Isoelectric Point: 10.6920

>AT154140 WP_022634630.1 NZ_CP051457:c3767668-3767171 [Dickeya solani]
MSQKRNNTTDVYAGADDVQETIRKLRQRVQERNVALEQMLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRR
MMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTLSEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILAT
APASR

Download         Length: 498 bp

>AT154140 NZ_CP067370:c2693672-2693406 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8VX87

Antitoxin

Source ID Structure

References