Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2716814..2717409 Replicon chromosome
Accession NZ_CP051457
Organism Dickeya solani strain IFB0167

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag HAT87_RS11975 Protein ID WP_013318177.1
Coordinates 2716814..2717191 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag HAT87_RS11980 Protein ID WP_022633800.1
Coordinates 2717188..2717409 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT87_RS11955 2712480..2712746 + 267 WP_022633797.1 hypothetical protein -
HAT87_RS11960 2712978..2713160 + 183 WP_072142890.1 hypothetical protein -
HAT87_RS11965 2713242..2715008 - 1767 WP_022633798.1 ATP-binding protein -
HAT87_RS11970 2714998..2716176 - 1179 WP_022633799.1 hypothetical protein -
HAT87_RS11975 2716814..2717191 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HAT87_RS11980 2717188..2717409 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HAT87_RS11985 2717550..2718698 - 1149 WP_022633801.1 L-threonine dehydrogenase -
HAT87_RS11990 2718980..2719540 + 561 WP_026594485.1 NUDIX domain-containing protein -
HAT87_RS11995 2719612..2720289 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
HAT87_RS12000 2720289..2721008 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T154139 WP_013318177.1 NZ_CP051457:c2717191-2716814 [Dickeya solani]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

>T154139 NZ_CP067370:2447387-2447704 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT154139 WP_022633800.1 NZ_CP051457:c2717409-2717188 [Dickeya solani]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp

>AT154139 NZ_CP067370:2447780-2448076 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References