Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1222455..1223080 Replicon chromosome
Accession NZ_CP051457
Organism Dickeya solani strain IFB0167

Toxin (Protein)


Gene name Hha Uniprot ID A0A2K8W3K4
Locus tag HAT87_RS05575 Protein ID WP_022632574.1
Coordinates 1222455..1222658 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8W3I1
Locus tag HAT87_RS05580 Protein ID WP_022632575.1
Coordinates 1222712..1223080 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT87_RS05545 1218095..1218433 + 339 WP_002208627.1 P-II family nitrogen regulator -
HAT87_RS05550 1218476..1219768 + 1293 WP_022632570.1 ammonium transporter AmtB -
HAT87_RS05555 1219864..1220727 - 864 WP_022632571.1 acyl-CoA thioesterase II -
HAT87_RS05560 1220979..1221536 + 558 WP_022632572.1 YbaY family lipoprotein -
HAT87_RS05565 1221565..1221894 - 330 WP_022632573.1 MGMT family protein -
HAT87_RS05575 1222455..1222658 - 204 WP_022632574.1 hemolysin expression modulator Hha Toxin
HAT87_RS05580 1222712..1223080 - 369 WP_022632575.1 Hha toxicity modulator TomB Antitoxin
HAT87_RS05585 1223588..1223731 - 144 WP_022632576.1 type B 50S ribosomal protein L36 -
HAT87_RS05590 1223747..1223998 - 252 WP_022632577.1 type B 50S ribosomal protein L31 -
HAT87_RS05595 1224175..1227321 - 3147 WP_022632578.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.52 Da        Isoelectric Point: 8.8580

>T154126 WP_022632574.1 NZ_CP051457:c1222658-1222455 [Dickeya solani]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T154126 NZ_CP067365:c533403-533218 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14223.06 Da        Isoelectric Point: 5.1663

>AT154126 WP_022632575.1 NZ_CP051457:c1223080-1222712 [Dickeya solani]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT154126 NZ_CP067365:c533703-533431 [Lacticaseibacillus rhamnosus]
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W3K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W3I1

References