Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 598174..598700 Replicon chromosome
Accession NZ_CP051457
Organism Dickeya solani strain IFB0167

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag HAT87_RS02790 Protein ID WP_022632051.1
Coordinates 598174..598479 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag HAT87_RS02795 Protein ID WP_022632052.1
Coordinates 598482..598700 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAT87_RS02770 593396..593793 + 398 Protein_537 DUF3577 domain-containing protein -
HAT87_RS02775 593909..595180 + 1272 WP_022632048.1 hypothetical protein -
HAT87_RS02780 595184..595756 + 573 WP_022632049.1 hypothetical protein -
HAT87_RS02785 595744..597684 + 1941 WP_022632050.1 hypothetical protein -
HAT87_RS02790 598174..598479 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
HAT87_RS02795 598482..598700 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HAT87_RS02800 598759..599502 - 744 WP_022632053.1 hypothetical protein -
HAT87_RS02805 600405..600755 - 351 WP_013316250.1 hypothetical protein -
HAT87_RS02810 600878..601066 + 189 WP_033111580.1 hypothetical protein -
HAT87_RS02815 601206..602465 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
HAT87_RS02825 602863..603438 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 592317..602642 10325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T154124 WP_022632051.1 NZ_CP051457:c598479-598174 [Dickeya solani]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T154124 NZ_CP067344:c119802-119404 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT154124 WP_022632052.1 NZ_CP051457:c598700-598482 [Dickeya solani]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT154124 NZ_CP067344:c120029-119802 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References