Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 918558..919128 Replicon chromosome
Accession NZ_CP051435
Organism Helicobacter pylori strain ASHA-005

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HGK50_RS04375 Protein ID WP_202135255.1
Coordinates 918558..918830 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HGK50_RS04380 Protein ID WP_202135257.1
Coordinates 918817..919128 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGK50_RS04355 915227..915996 - 770 Protein_853 ABC transporter ATP-binding protein -
HGK50_RS04360 915996..916976 - 981 WP_202132518.1 iron ABC transporter permease -
HGK50_RS04365 916969..917811 - 843 WP_202132519.1 SDR family oxidoreductase -
HGK50_RS04370 917952..918476 + 525 WP_001120215.1 acyl-CoA thioesterase -
HGK50_RS04375 918558..918830 - 273 WP_202135255.1 type II toxin-antitoxin system YafQ family toxin Toxin
HGK50_RS04380 918817..919128 - 312 WP_202135257.1 hypothetical protein Antitoxin
HGK50_RS04385 919412..921640 - 2229 WP_202147955.1 outer membrane beta-barrel protein -
HGK50_RS04400 922102..922623 + 522 WP_202132523.1 hypothetical protein -
HGK50_RS04405 922574..923686 - 1113 WP_202147956.1 hydrogenase formation protein HypD -
HGK50_RS04410 923705..923941 - 237 WP_078284132.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10649.63 Da        Isoelectric Point: 9.7265

>T154121 WP_202135255.1 NZ_CP051435:c918830-918558 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKFLYKVVENLAKEQPLDPKYKDHPLKGTLKDFRECHLKPDLLLVYQVKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T154121 NZ_CP067342:c4373613-4373440 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12302.17 Da        Isoelectric Point: 10.3492

>AT154121 WP_202135257.1 NZ_CP051435:c919128-918817 [Helicobacter pylori]
MPNSPTKKDFTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT154121 NZ_CP067342:c4373937-4373641 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References