Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 928666..929290 Replicon chromosome
Accession NZ_CP051434
Organism Helicobacter pylori strain ASHA-004

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HGK49_RS04485 Protein ID WP_202132520.1
Coordinates 928666..928932 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HGK49_RS04490 Protein ID WP_202132521.1
Coordinates 928913..929290 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGK49_RS04465 925315..926082 - 768 WP_202132517.1 ABC transporter ATP-binding protein -
HGK49_RS04470 926082..927062 - 981 WP_202132518.1 iron ABC transporter permease -
HGK49_RS04475 927055..927897 - 843 WP_202132519.1 SDR family oxidoreductase -
HGK49_RS04480 928038..928562 + 525 WP_001120215.1 acyl-CoA thioesterase -
HGK49_RS04485 928666..928932 - 267 WP_202132520.1 type II toxin-antitoxin system YafQ family toxin Toxin
HGK49_RS04490 928913..929290 - 378 WP_202132521.1 hypothetical protein Antitoxin
HGK49_RS04495 929574..931799 - 2226 WP_202132522.1 outer membrane beta-barrel protein -
HGK49_RS04510 932261..932782 + 522 WP_202132523.1 hypothetical protein -
HGK49_RS04515 932733..933845 - 1113 WP_202132524.1 hydrogenase formation protein HypD -
HGK49_RS04520 933864..934100 - 237 WP_078284132.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.14 Da        Isoelectric Point: 8.0602

>T154120 WP_202132520.1 NZ_CP051434:c928932-928666 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T154120 NZ_CP067342:4361020-4361397 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14731.75 Da        Isoelectric Point: 8.4773

>AT154120 WP_202132521.1 NZ_CP051434:c929290-928913 [Helicobacter pylori]
MPNSPTKKDFTRYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQVFDDKRDCCL
GHEIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 378 bp

>AT154120 NZ_CP067342:4360599-4360973 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References