Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 24663..25185 Replicon plasmid pSCLE2
Accession NZ_CP051432
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HGD79_RS25630 Protein ID WP_000220560.1
Coordinates 24904..25185 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HGD79_RS25625 Protein ID WP_000121743.1
Coordinates 24663..24914 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS25595 20026..20256 + 231 WP_000051064.1 partitioning protein -
HGD79_RS25600 20272..20565 + 294 WP_015060510.1 hypothetical protein -
HGD79_RS25605 20567..21535 + 969 WP_077783213.1 IS5 family transposase -
HGD79_RS25610 21595..22017 - 423 WP_031942371.1 DNA distortion polypeptide 3 -
HGD79_RS25615 22085..22531 - 447 WP_001074386.1 hypothetical protein -
HGD79_RS25620 22571..23407 - 837 WP_001050931.1 replication initiation protein -
HGD79_RS25625 24663..24914 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HGD79_RS25630 24904..25185 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGD79_RS25635 25331..25654 + 324 WP_001181903.1 hypothetical protein -
HGD79_RS25640 25699..25944 + 246 WP_000356546.1 hypothetical protein -
HGD79_RS25645 25934..26149 + 216 WP_001180116.1 hypothetical protein -
HGD79_RS25650 26242..26571 + 330 WP_000866648.1 hypothetical protein -
HGD79_RS25655 26858..27007 + 150 WP_000003880.1 hypothetical protein -
HGD79_RS25660 27020..27292 + 273 WP_000160399.1 hypothetical protein -
HGD79_RS25665 27619..28164 + 546 WP_025755763.1 hypothetical protein -
HGD79_RS25670 28167..29324 + 1158 WP_000538023.1 hypothetical protein -
HGD79_RS25675 29685..30176 + 492 WP_000872475.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR - 1..45814 45814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T154117 WP_000220560.1 NZ_CP051432:24904-25185 [Escherichia sp. SCLE84]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T154117 NZ_CP067342:3531377-3531919 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACTCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT154117 WP_000121743.1 NZ_CP051432:24663-24914 [Escherichia sp. SCLE84]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT154117 NZ_CP067342:3531082-3531393 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References