Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4624578..4625203 Replicon chromosome
Accession NZ_CP051430
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HGD79_RS22490 Protein ID WP_000911330.1
Coordinates 4624805..4625203 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HGD79_RS22485 Protein ID WP_000450524.1
Coordinates 4624578..4624805 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS22460 4620381..4620851 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
HGD79_RS22465 4620851..4621423 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HGD79_RS22470 4621569..4622447 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
HGD79_RS22475 4622464..4623498 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
HGD79_RS22480 4623711..4624424 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HGD79_RS22485 4624578..4624805 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HGD79_RS22490 4624805..4625203 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
HGD79_RS22495 4625350..4626213 + 864 WP_001267507.1 neutral zinc metallopeptidase -
HGD79_RS22500 4626228..4628243 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
HGD79_RS22505 4628317..4629015 + 699 WP_000679812.1 esterase -
HGD79_RS22510 4629096..4629296 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T154114 WP_000911330.1 NZ_CP051430:4624805-4625203 [Escherichia sp. SCLE84]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T154114 NZ_CP067342:2744646-2744753 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT154114 WP_000450524.1 NZ_CP051430:4624578-4624805 [Escherichia sp. SCLE84]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT154114 NZ_CP067342:c2744599-2744533 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References