Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3554561..3555192 Replicon chromosome
Accession NZ_CP051430
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag HGD79_RS17155 Protein ID WP_001259385.1
Coordinates 3554561..3554836 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag HGD79_RS17160 Protein ID WP_000593554.1
Coordinates 3554833..3555192 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS17140 3549565..3550632 + 1068 WP_000361467.1 HlyD family secretion protein -
HGD79_RS17145 3550629..3553364 + 2736 WP_168848454.1 ribosome-associated ATPase/putative transporter RbbA -
HGD79_RS17150 3553364..3554488 + 1125 WP_001216257.1 ABC transporter permease -
HGD79_RS17155 3554561..3554836 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
HGD79_RS17160 3554833..3555192 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HGD79_RS17165 3555242..3556102 - 861 WP_001131783.1 class II aldolase -
HGD79_RS17170 3556134..3556403 - 270 WP_000933060.1 HPr family phosphocarrier protein -
HGD79_RS17175 3556393..3557901 - 1509 WP_001298718.1 carbohydrate kinase -
HGD79_RS17180 3557894..3559252 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
HGD79_RS17185 3559329..3559610 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
HGD79_RS17190 3559607..3560080 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3546944..3555192 8248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T154110 WP_001259385.1 NZ_CP051430:3554561-3554836 [Escherichia sp. SCLE84]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T154110 NZ_CP067342:2107229-2107332 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT154110 WP_000593554.1 NZ_CP051430:3554833-3555192 [Escherichia sp. SCLE84]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT154110 NZ_CP067342:c2107370-2107099 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References