Detailed information of TA system TA154109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 2871152..2872140
• Replicon: chromosome
• Accession: NZ_CP051430
• Organism: Escherichia sp. SCLE84

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HGD79_RS14065
• Protein ID: WP_014640052.1
• Coordinates: 2871152..2871538 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: HGD79_RS14070
• Protein ID: WP_000458584.1
• Coordinates: 2871568..2872140 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGD79_RS14020	2866425..2866786	+	362	Protein_2756	hypothetical protein	-
HGD79_RS14025	2866852..2867676	+	825	WP_000081297.1	YfdQ family protein	-
HGD79_RS14030	2867804..2868340	+	537	WP_000008180.1	5'-deoxynucleotidase	-
HGD79_RS14035	2868331..2868918	+	588	WP_039022222.1	hypothetical protein	-
HGD79_RS14040	2868920..2869111	+	192	WP_001743084.1	hypothetical protein	-
HGD79_RS14045	2869114..2870001	+	888	WP_039022220.1	DUF551 domain-containing protein	-
HGD79_RS14050	2870001..2870573	+	573	WP_057688084.1	3'-5' exoribonuclease	-
HGD79_RS14055	2870610..2870891	+	282	WP_001093917.1	pyocin activator PrtN family protein	-
HGD79_RS14060	2870939..2871112	-	174	WP_000390072.1	hypothetical protein	-
HGD79_RS14065	2871152..2871538	-	387	WP_014640052.1	hypothetical protein	Toxin
HGD79_RS14070	2871568..2872140	-	573	WP_000458584.1	SocA family protein	Antitoxin
HGD79_RS14075	2872376..2872498	-	123	WP_001382617.1	hypothetical protein	-
HGD79_RS14080	2872862..2873884	-	1023	Protein_2768	DUF2713 family protein	-
HGD79_RS14085	2874202..2874717	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
HGD79_RS14090	2874759..2874968	-	210	WP_001030593.1	CsbD family protein	-
HGD79_RS14095	2875084..2876409	-	1326	WP_001295692.1	MATE family efflux transporter DinF	-
HGD79_RS14100	2876482..2877090	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2826186..2877090	50904

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T154109 WP_014640052.1 NZ_CP051430:c2871538-2871152 [Escherichia sp. SCLE84]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T154109 NZ_CP067342:1921828-1922082 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT154109 WP_000458584.1 NZ_CP051430:c2872140-2871568 [Escherichia sp. SCLE84]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT154109 NZ_CP067342:1921580-1921831 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCGCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5