Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1929617..1930235 Replicon chromosome
Accession NZ_CP051430
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HGD79_RS09570 Protein ID WP_001291435.1
Coordinates 1930017..1930235 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HGD79_RS09565 Protein ID WP_000344800.1
Coordinates 1929617..1929991 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS09555 1924706..1925899 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HGD79_RS09560 1925922..1929071 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HGD79_RS09565 1929617..1929991 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HGD79_RS09570 1930017..1930235 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HGD79_RS09575 1930406..1930957 + 552 WP_000102564.1 maltose O-acetyltransferase -
HGD79_RS09580 1931073..1931543 + 471 WP_000136192.1 YlaC family protein -
HGD79_RS09585 1931707..1933257 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HGD79_RS09590 1933299..1933652 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HGD79_RS09600 1934031..1934342 + 312 WP_000409911.1 MGMT family protein -
HGD79_RS09605 1934373..1934945 - 573 WP_000779826.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T154104 WP_001291435.1 NZ_CP051430:1930017-1930235 [Escherichia sp. SCLE84]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T154104 NZ_CP067342:849113-849601 [Escherichia coli]
ATGATCTCCGCTCCTGAGCCGCTTCACGCCGGGCATATTCTTACCCCATTTTGCTGTGGCGTGGATTCTATGGATAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGTACTTTTGTATGTTGCGGCAGTGATTCTAAGGTAC
TGGCGTATTACTCGCTGGCATCCAGTGCAGTGACGACAAACACTGCCCCCGGCCGCTTTCGCCGTAATATGCCCGATCCG
ATCCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATCAGTCTATACATGGGCAGGGTGTTGGTCGGGCGCTGGTACGTGA
CGCCGGGCTGCGGGTGATTCAGGTGGCTGAAACTATTGGTATTCGCGGGATGCTGGTTCATGCGCTGTCTGATGAGGCGC
GGGATTTCTATCTGCGGGTGGGGTTTGAGCCGTCACCGATGGATCCGATGATGTTGCTGGTGACGTTGGGGGATTTGGTT
CATGCTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT154104 WP_000344800.1 NZ_CP051430:1929617-1929991 [Escherichia sp. SCLE84]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT154104 NZ_CP067342:848823-849116 [Escherichia coli]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAATCTGCGCATCAGGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCGAAAGCCAGAGGAAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGCGCCGCGGCGGAAGAGGCGCTGA
TCGAGCAGCGTATCATTATGGCCGATCCGGAGGCTTATCAGACGTTTCTTACCCGCCTTGATCAGGCTCCAGCGCCAAAC
TCCGCGCTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References