Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1162666..1163501 | Replicon | chromosome |
| Accession | NZ_CP051430 | ||
| Organism | Escherichia sp. SCLE84 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6H2GFM1 |
| Locus tag | HGD79_RS05945 | Protein ID | WP_065304416.1 |
| Coordinates | 1162666..1163043 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A6H2GGB7 |
| Locus tag | HGD79_RS05950 | Protein ID | WP_001285390.1 |
| Coordinates | 1163133..1163501 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HGD79_RS05905 | 1157936..1158427 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| HGD79_RS05910 | 1158529..1159083 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| HGD79_RS05915 | 1159107..1159844 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| HGD79_RS05920 | 1159899..1160837 | - | 939 | WP_096147332.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| HGD79_RS05930 | 1161308..1162150 | - | 843 | WP_065304417.1 | DUF4942 domain-containing protein | - |
| HGD79_RS05935 | 1162247..1162444 | - | 198 | WP_086598277.1 | DUF957 domain-containing protein | - |
| HGD79_RS05940 | 1162490..1162669 | - | 180 | Protein_1174 | hypothetical protein | - |
| HGD79_RS05945 | 1162666..1163043 | - | 378 | WP_065304416.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| HGD79_RS05950 | 1163133..1163501 | - | 369 | WP_001285390.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HGD79_RS05955 | 1163551..1164195 | - | 645 | WP_065304415.1 | antitoxin of toxin-antitoxin stability system | - |
| HGD79_RS05960 | 1164210..1164431 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| HGD79_RS05965 | 1164500..1164976 | - | 477 | WP_001186747.1 | RadC family protein | - |
| HGD79_RS05970 | 1164991..1165476 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| HGD79_RS05975 | 1165567..1166388 | - | 822 | WP_106668205.1 | DUF945 domain-containing protein | - |
| HGD79_RS05980 | 1166609..1167019 | - | 411 | WP_000846713.1 | hypothetical protein | - |
| HGD79_RS05985 | 1167035..1167712 | - | 678 | WP_059239983.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | csgC / csgA / csgB / csgD / csgE / csgF / csgG | 1153431..1193649 | 40218 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14060.06 Da Isoelectric Point: 7.8522
>T154103 WP_065304416.1 NZ_CP051430:c1163043-1162666 [Escherichia sp. SCLE84]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKQ
Download Length: 378 bp
>T154103 NZ_CP067342:716802-717185 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13811.52 Da Isoelectric Point: 5.9618
>AT154103 WP_001285390.1 NZ_CP051430:c1163501-1163133 [Escherichia sp. SCLE84]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT154103 NZ_CP067342:716344-716712 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H2GFM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6H2GGB7 |