Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 623979..624505 Replicon chromosome
Accession NZ_CP051430
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HGD79_RS03290 Protein ID WP_000323025.1
Coordinates 624218..624505 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HGD79_RS03285 Protein ID WP_000534858.1
Coordinates 623979..624218 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS03260 619313..619669 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
HGD79_RS26340 620280..620567 + 288 Protein_642 hypothetical protein -
HGD79_RS03270 621336..622677 + 1342 Protein_643 ISNCY family transposase -
HGD79_RS03275 623114..623446 - 333 WP_001317460.1 FlxA-like family protein -
HGD79_RS03280 623649..623954 - 306 WP_168848292.1 hypothetical protein -
HGD79_RS03285 623979..624218 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HGD79_RS03290 624218..624505 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HGD79_RS03295 624577..624732 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HGD79_RS03300 624949..625200 + 252 WP_000980994.1 hypothetical protein -
HGD79_RS03305 625267..625545 + 279 WP_012304870.1 hypothetical protein -
HGD79_RS03310 625547..626596 + 1050 WP_168848293.1 DUF968 domain-containing protein -
HGD79_RS03315 626610..627362 + 753 WP_001047135.1 antitermination protein -
HGD79_RS03320 627640..627729 - 90 WP_120795389.1 hypothetical protein -
HGD79_RS03325 627784..627996 - 213 WP_000087756.1 cold shock-like protein CspF -
HGD79_RS03330 628297..628512 + 216 WP_000066484.1 cold shock-like protein CspB -
HGD79_RS03335 629266..629481 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 599082..659733 60651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T154101 WP_000323025.1 NZ_CP051430:624218-624505 [Escherichia sp. SCLE84]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T154101 NZ_CP067342:212811-212918 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT154101 WP_000534858.1 NZ_CP051430:623979-624218 [Escherichia sp. SCLE84]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT154101 NZ_CP067342:c212763-212697 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References