Detailed information of TA system TA154091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3119547..3120100
• Replicon: chromosome
• Accession: NZ_CP051429
• Organism: Dickeya dianthicola strain 67-19

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HGI48_RS13950
• Protein ID: WP_192988884.1
• Coordinates: 3119547..3119861 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: HGI48_RS13955
• Protein ID: WP_110372302.1
• Coordinates: 3119864..3120100 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI48_RS13940	3118906..3119280	+	375	Protein_2734	hypothetical protein	-
HGI48_RS13945	3119278..3119550	+	273	Protein_2735	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
HGI48_RS13950	3119547..3119861	-	315	WP_192988884.1	CcdB family protein	Toxin
HGI48_RS13955	3119864..3120100	-	237	WP_110372302.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HGI48_RS13960	3120421..3120591	-	171	Protein_2738	DNA primase	-
HGI48_RS13965	3120666..3122525	-	1860	WP_192988885.1	hypothetical protein	-
HGI48_RS13970	3123167..3123943	-	777	Protein_2740	DUF1738 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11493.40 Da
• Isoelectric Point: 7.9859

>T154091 WP_192988884.1 NZ_CP051429:c3119861-3119547 [Dickeya dianthicola]
MQFTVYGNTGKSGVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERFVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T154091 NZ_CP067311:3915738-3916073 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9031.05 Da
• Isoelectric Point: 6.4792

>AT154091 WP_110372302.1 NZ_CP051429:c3120100-3119864 [Dickeya dianthicola]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRHHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT154091 NZ_CP067311:3915490-3915738 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA