Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2607101..2607696 Replicon chromosome
Accession NZ_CP051429
Organism Dickeya dianthicola strain 67-19

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HGI48_RS11945 Protein ID WP_192988630.1
Coordinates 2607101..2607478 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HGI48_RS11950 Protein ID WP_161132889.1
Coordinates 2607475..2607696 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI48_RS11915 2602132..2603163 + 1032 WP_192988626.1 methionine synthase -
HGI48_RS11920 2603222..2603428 + 207 Protein_2339 glutamine amidotransferase -
HGI48_RS11925 2603563..2604918 - 1356 WP_192988627.1 alkyl/aryl-sulfatase -
HGI48_RS11930 2605038..2605481 - 444 WP_192988628.1 alpha/beta hydrolase -
HGI48_RS11935 2605601..2606512 + 912 WP_192988629.1 LysR family transcriptional regulator -
HGI48_RS11940 2606481..2607080 - 600 WP_192991481.1 substrate binding domain-containing protein -
HGI48_RS11945 2607101..2607478 - 378 WP_192988630.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HGI48_RS11950 2607475..2607696 - 222 WP_161132889.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGI48_RS11955 2608080..2608460 - 381 WP_192988631.1 antibiotic biosynthesis monooxygenase -
HGI48_RS11960 2608527..2609420 - 894 WP_192988632.1 NAD(P)/FAD-dependent oxidoreductase -
HGI48_RS11965 2609547..2610200 + 654 WP_192988633.1 TetR/AcrR family transcriptional regulator -
HGI48_RS11970 2610459..2610890 - 432 WP_192988634.1 VOC family protein -
HGI48_RS11975 2611000..2611596 + 597 WP_192988635.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2599619..2610890 11271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14207.30 Da        Isoelectric Point: 5.7411

>T154090 WP_192988630.1 NZ_CP051429:c2607478-2607101 [Dickeya dianthicola]
MKWVSAQDVIAFHDRILQVLPGVAGMADPGRAEALIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGVLIVDNDNSLEELTVKAAMGECQVSELAEQLRQRVEK

Download         Length: 378 bp

>T154090 NZ_CP067311:3794524-3794931 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8234.35 Da        Isoelectric Point: 5.7996

>AT154090 WP_161132889.1 NZ_CP051429:c2607696-2607475 [Dickeya dianthicola]
MKTYTITEARQNIATVIDTAASGEPVEITRRDGTSAVLIPKAEFEVYQKARLDAEFDFIMQRHGYTIKALADR

Download         Length: 222 bp

>AT154090 NZ_CP067311:3794277-3794543 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References