Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1216824..1217449 Replicon chromosome
Accession NZ_CP051429
Organism Dickeya dianthicola strain 67-19

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag HGI48_RS05770 Protein ID WP_009114000.1
Coordinates 1216824..1217027 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3A4CQB3
Locus tag HGI48_RS05775 Protein ID WP_024104994.1
Coordinates 1217081..1217449 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI48_RS05740 1212305..1212643 + 339 WP_024104989.1 P-II family nitrogen regulator -
HGI48_RS05745 1212686..1213978 + 1293 WP_024104990.1 ammonium transporter AmtB -
HGI48_RS05750 1214080..1214943 - 864 WP_024104991.1 acyl-CoA thioesterase II -
HGI48_RS05755 1215215..1215772 + 558 WP_192990626.1 YbaY family lipoprotein -
HGI48_RS05760 1215801..1216130 - 330 WP_161131559.1 MGMT family protein -
HGI48_RS05770 1216824..1217027 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
HGI48_RS05775 1217081..1217449 - 369 WP_024104994.1 Hha toxicity modulator TomB Antitoxin
HGI48_RS05780 1217958..1218101 - 144 WP_192990627.1 type B 50S ribosomal protein L36 -
HGI48_RS05785 1218117..1218368 - 252 WP_024108457.1 type B 50S ribosomal protein L31 -
HGI48_RS05790 1218539..1221688 - 3150 WP_024104996.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T154079 WP_009114000.1 NZ_CP051429:c1217027-1216824 [Dickeya dianthicola]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T154079 NZ_CP067311:933463-933570 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT154079 WP_024104994.1 NZ_CP051429:c1217449-1217081 [Dickeya dianthicola]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRSWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWRKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT154079 NZ_CP067311:c933416-933350 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3A4CQB3

References