Detailed information of TA system TA154078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1108347..1110030
• Replicon: chromosome
• Accession: NZ_CP051429
• Organism: Dickeya dianthicola strain 67-19

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HGI48_RS05285
• Protein ID: WP_192990561.1
• Coordinates: 1109113..1110030 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HGI48_RS05280
• Protein ID: WP_192990560.1
• Coordinates: 1108347..1109120 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI48_RS05255	1103843..1103974	-	132	Protein_1023	IS3 family transposase	-
HGI48_RS05260	1104041..1104271	+	231	Protein_1024	transposase	-
HGI48_RS05265	1104376..1106091	-	1716	WP_192990558.1	ATP-binding protein	-
HGI48_RS05270	1106091..1107275	-	1185	WP_192990559.1	hypothetical protein	-
HGI48_RS05275	1107874..1108243	-	370	Protein_1027	transposase	-
HGI48_RS05280	1108347..1109120	+	774	WP_192990560.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HGI48_RS05285	1109113..1110030	+	918	WP_192990561.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HGI48_RS05290	1110572..1111207	-	636	WP_192990562.1	NAD(P)H-binding protein	-
HGI48_RS05295	1111374..1111763	-	390	WP_192990563.1	DoxX family protein	-
HGI48_RS05300	1111919..1112293	+	375	WP_192990564.1	helix-turn-helix transcriptional regulator	-
HGI48_RS05305	1112456..1113196	-	741	WP_192990565.1	SDR family oxidoreductase	-
HGI48_RS05310	1113281..1113985	+	705	WP_192990566.1	TetR/AcrR family transcriptional regulator	-
HGI48_RS05315	1113930..1114136	-	207	Protein_1035	helix-turn-helix transcriptional regulator	-
HGI48_RS05320	1114191..1114985	-	795	WP_192990567.1	aspartyl/asparaginyl beta-hydroxylase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1100286..1124674	24388

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (96-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34647.97 Da
• Isoelectric Point: 4.9786

>T154078 WP_192990561.1 NZ_CP051429:1109113-1110030 [Dickeya dianthicola]
MDKQSPYYRQVALLLNALPVVAVERCFALKGGTAINLFVRDFPRLSVDIDLAYIPLESRDVALPNVRAALMRITERLQQQ
VGISAVLQTNNPDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDVVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
SRDFYDVKMLLETQGIDRQIFNGFITYLLGHKRPLSEILDPHWKDISELYANEFNGMTFDAASLEELNAIPKLMVAALKA
YFTQQDYDFLMSFKRGEPDWSLAPEDQIQHLPAVKWKLQNIVRMPKEKHIQALAKLEAVLAEWIK

Nucleotide

• Length: 918 bp

>T154078 NZ_CP067311:c724907-724731 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 28935.39 Da
• Isoelectric Point: 10.0837

>AT154078 WP_192990560.1 NZ_CP051429:1108347-1109120 [Dickeya dianthicola]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLASKYMHSNWLQKLRAGVYVRSGRDPQWSDAVLGLQNQLGISVHLAGLT
SLTWQGRAHYLHLTRQAIWLCVEDKASLPKWFKEFPNVEWLLLSNQKLNMHDEKYLTEVEIKGERLKASIPELAAYEVAN
LVPGLLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVKRIDKANIDLGAGKRQIVSGGKLDQK
YQITVPESFVSKGISHG

Nucleotide

• Length: 774 bp

>AT154078 NZ_CP067311:c724685-724269 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA