Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1108347..1110030 Replicon chromosome
Accession NZ_CP051429
Organism Dickeya dianthicola strain 67-19

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag HGI48_RS05285 Protein ID WP_192990561.1
Coordinates 1109113..1110030 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag HGI48_RS05280 Protein ID WP_192990560.1
Coordinates 1108347..1109120 (+) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI48_RS05255 1103843..1103974 - 132 Protein_1023 IS3 family transposase -
HGI48_RS05260 1104041..1104271 + 231 Protein_1024 transposase -
HGI48_RS05265 1104376..1106091 - 1716 WP_192990558.1 ATP-binding protein -
HGI48_RS05270 1106091..1107275 - 1185 WP_192990559.1 hypothetical protein -
HGI48_RS05275 1107874..1108243 - 370 Protein_1027 transposase -
HGI48_RS05280 1108347..1109120 + 774 WP_192990560.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
HGI48_RS05285 1109113..1110030 + 918 WP_192990561.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HGI48_RS05290 1110572..1111207 - 636 WP_192990562.1 NAD(P)H-binding protein -
HGI48_RS05295 1111374..1111763 - 390 WP_192990563.1 DoxX family protein -
HGI48_RS05300 1111919..1112293 + 375 WP_192990564.1 helix-turn-helix transcriptional regulator -
HGI48_RS05305 1112456..1113196 - 741 WP_192990565.1 SDR family oxidoreductase -
HGI48_RS05310 1113281..1113985 + 705 WP_192990566.1 TetR/AcrR family transcriptional regulator -
HGI48_RS05315 1113930..1114136 - 207 Protein_1035 helix-turn-helix transcriptional regulator -
HGI48_RS05320 1114191..1114985 - 795 WP_192990567.1 aspartyl/asparaginyl beta-hydroxylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1100286..1124674 24388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(96-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34647.97 Da        Isoelectric Point: 4.9786

>T154078 WP_192990561.1 NZ_CP051429:1109113-1110030 [Dickeya dianthicola]
MDKQSPYYRQVALLLNALPVVAVERCFALKGGTAINLFVRDFPRLSVDIDLAYIPLESRDVALPNVRAALMRITERLQQQ
VGISAVLQTNNPDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDVVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
SRDFYDVKMLLETQGIDRQIFNGFITYLLGHKRPLSEILDPHWKDISELYANEFNGMTFDAASLEELNAIPKLMVAALKA
YFTQQDYDFLMSFKRGEPDWSLAPEDQIQHLPAVKWKLQNIVRMPKEKHIQALAKLEAVLAEWIK

Download         Length: 918 bp

>T154078 NZ_CP067311:c724907-724731 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 28935.39 Da        Isoelectric Point: 10.0837

>AT154078 WP_192990560.1 NZ_CP051429:1108347-1109120 [Dickeya dianthicola]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLASKYMHSNWLQKLRAGVYVRSGRDPQWSDAVLGLQNQLGISVHLAGLT
SLTWQGRAHYLHLTRQAIWLCVEDKASLPKWFKEFPNVEWLLLSNQKLNMHDEKYLTEVEIKGERLKASIPELAAYEVAN
LVPGLLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVKRIDKANIDLGAGKRQIVSGGKLDQK
YQITVPESFVSKGISHG

Download         Length: 774 bp

>AT154078 NZ_CP067311:c724685-724269 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References