Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 989158..989942 Replicon chromosome
Accession NZ_CP051429
Organism Dickeya dianthicola strain 67-19

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag HGI48_RS04715 Protein ID WP_192991409.1
Coordinates 989448..989942 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag HGI48_RS04710 Protein ID WP_192990491.1
Coordinates 989158..989451 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI48_RS04680 984842..985567 + 726 WP_192990487.1 Expansin-YoaJ -
HGI48_RS04685 985638..986585 + 948 WP_192990488.1 glycoside hydrolase family 5 protein -
HGI48_RS04690 986697..986858 - 162 WP_161132386.1 CcdB family protein -
HGI48_RS04695 986867..987004 - 138 Protein_914 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
HGI48_RS04700 987515..988168 - 654 WP_192990489.1 RES family NAD+ phosphorylase -
HGI48_RS04705 988161..988880 - 720 WP_192990490.1 hypothetical protein -
HGI48_RS04710 989158..989451 + 294 WP_192990491.1 DUF1778 domain-containing protein Antitoxin
HGI48_RS04715 989448..989942 + 495 WP_192991409.1 GNAT family N-acetyltransferase Toxin
HGI48_RS04720 990158..990442 + 285 WP_168640622.1 hypothetical protein -
HGI48_RS04725 990445..990563 + 119 Protein_920 HTH domain-containing protein -
HGI48_RS04730 991378..992454 + 1077 WP_192990492.1 hypothetical protein -
HGI48_RS04735 992485..993561 + 1077 WP_192990493.1 hypothetical protein -
HGI48_RS04740 993581..994276 + 696 WP_192990494.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 984842..1020927 36085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17756.60 Da        Isoelectric Point: 7.2151

>T154076 WP_192991409.1 NZ_CP051429:989448-989942 [Dickeya dianthicola]
MISAPEPLRAEHVLSSFCCGVESMDNWLKQRAMKNQLTGASRTFVSCDDSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMILMVTLGDLVD
SLSI

Download         Length: 495 bp

>T154076 NZ_CP067311:307379-307482 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10887.46 Da        Isoelectric Point: 10.4623

>AT154076 WP_192990491.1 NZ_CP051429:989158-989451 [Dickeya dianthicola]
MSATNRVSAKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT154076 NZ_CP067311:c307520-307249 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References