Detailed information of TA system TA154075

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 719513..720191
• Replicon: chromosome
• Accession: NZ_CP051429
• Organism: Dickeya dianthicola strain 67-19

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HGI48_RS03425
• Protein ID: WP_192990305.1
• Coordinates: 719760..720191 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HGI48_RS03420
• Protein ID: WP_192991400.1
• Coordinates: 719513..719779 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI48_RS03405	716613..717221	-	609	WP_192990302.1	HD domain-containing protein	-
HGI48_RS03410	717495..718145	+	651	WP_192990303.1	hemolysin III family protein	-
HGI48_RS03415	718219..719199	-	981	WP_192990304.1	tRNA-modifying protein YgfZ	-
HGI48_RS03420	719513..719779	+	267	WP_192991400.1	FAD assembly factor SdhE	Antitoxin
HGI48_RS03425	719760..720191	+	432	WP_192990305.1	protein YgfX	Toxin
HGI48_RS03430	720286..720804	-	519	WP_192990306.1	flavodoxin FldB	-
HGI48_RS03435	720933..722258	-	1326	WP_192990307.1	MHS family MFS transporter	-
HGI48_RS03440	722531..723430	+	900	WP_024104639.1	site-specific tyrosine recombinase XerD	-
HGI48_RS03445	723520..724236	+	717	WP_024104640.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16867.60 Da
• Isoelectric Point: 11.7737

>T154075 WP_192990305.1 NZ_CP051429:719760-720191 [Dickeya dianthicola]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQMVRRPWVMRNGVLLSLRATNGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T154075 NZ_CP067309:25247-25528 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGTGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTACCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10460.98 Da
• Isoelectric Point: 6.0666

>AT154075 WP_192991400.1 NZ_CP051429:719513-719779 [Dickeya dianthicola]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKLHFIRLLQCDDPDLFNWLMNHGEPVDSALKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT154075 NZ_CP067309:25006-25257 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA