Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1425413..1426048 Replicon chromosome
Accession NZ_CP051428
Organism Paenibacillus sp. UniB2

Toxin (Protein)


Gene name mazF Uniprot ID A0A2N5N3G9
Locus tag HGI30_RS06235 Protein ID WP_028600569.1
Coordinates 1425698..1426048 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2N5N3F8
Locus tag HGI30_RS06230 Protein ID WP_028600570.1
Coordinates 1425413..1425694 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI30_RS06215 1420894..1422240 - 1347 WP_168909758.1 extracellular solute-binding protein -
HGI30_RS06220 1422735..1423865 + 1131 WP_168906850.1 outer membrane lipoprotein carrier protein LolA -
HGI30_RS06225 1424037..1425230 + 1194 WP_168906851.1 alanine racemase -
HGI30_RS06230 1425413..1425694 + 282 WP_028600570.1 ribbon-helix-helix protein, CopG family Antitoxin
HGI30_RS06235 1425698..1426048 + 351 WP_028600569.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HGI30_RS06240 1426274..1426993 + 720 WP_168906852.1 flagellar biosynthesis protein FlgA -
HGI30_RS06245 1426990..1427826 + 837 WP_168906853.1 hypothetical protein -
HGI30_RS06250 1427823..1429226 + 1404 WP_168906854.1 Flp pilus assembly complex ATPase component TadA -
HGI30_RS06255 1429219..1430160 + 942 WP_168909759.1 type II secretion system F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12930.88 Da        Isoelectric Point: 5.1336

>T154073 WP_028600569.1 NZ_CP051428:1425698-1426048 [Paenibacillus sp. UniB2]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKEHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMRHVDDALQISVGLIDF

Download         Length: 351 bp

>T154073 NZ_CP067308:85582-86907 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10689.35 Da        Isoelectric Point: 8.5543

>AT154073 WP_028600570.1 NZ_CP051428:1425413-1425694 [Paenibacillus sp. UniB2]
VANVQNTKRIMISIPDHLLEEVDGIVAKENSNRSEFIRQAMKLYLVERKKRQIRELMQRGYLEMAKINLNMASEAFQAEE
DADRALGRLVSGV

Download         Length: 282 bp

>AT154073 NZ_CP067308:85284-85577 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N5N3G9

Antitoxin

Source ID Structure
AlphaFold DB A0A2N5N3F8

References