Detailed information of TA system TA154072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1024403..1025064
• Replicon: chromosome
• Accession: NZ_CP051428
• Organism: Paenibacillus sp. UniB2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HGI30_RS04515
• Protein ID: WP_168906549.1
• Coordinates: 1024639..1025064 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HGI30_RS04510
• Protein ID: WP_168906548.1
• Coordinates: 1024403..1024642 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGI30_RS04490	1019517..1020761	+	1245	WP_168906545.1	YbfB/YjiJ family MFS transporter	-
HGI30_RS04495	1020758..1021462	-	705	WP_168906546.1	hypothetical protein	-
HGI30_RS04500	1021644..1022969	+	1326	WP_168906547.1	PQQ-binding-like beta-propeller repeat protein	-
HGI30_RS04505	1023063..1024211	-	1149	WP_206110016.1	copper amine oxidase N-terminal domain-containing protein	-
HGI30_RS04510	1024403..1024642	+	240	WP_168906548.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HGI30_RS04515	1024639..1025064	+	426	WP_168906549.1	type II toxin-antitoxin system VapC family toxin	Toxin
HGI30_RS04520	1025102..1026340	+	1239	WP_168906550.1	multidrug effflux MFS transporter	-
HGI30_RS04525	1026488..1027315	+	828	WP_168909728.1	aminoglycoside phosphotransferase family protein	-
HGI30_RS04530	1027471..1028778	+	1308	WP_168906551.1	MFS transporter	-
HGI30_RS04535	1028840..1029091	-	252	WP_168906552.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-58)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16031.32 Da
• Isoelectric Point: 5.2312

>T154072 WP_168906549.1 NZ_CP051428:1024639-1025064 [Paenibacillus sp. UniB2]
MNYLLDTNVISELVKKEPDSGVLRWIDERDESTLFLSVITFGELQKGVSKLSDKNRAQRLQAWIDQDLSSRFDGRVLPLD
LDTLLVWGNIQGLSERNETPLPVMDSLIAATAIAHRLTVVTRNVHDLERCKASVFNPWINK

Nucleotide

• Length: 426 bp

>T154072 NZ_CP067307:c4797071-4796964 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9047.31 Da
• Isoelectric Point: 5.0628

>AT154072 WP_168906548.1 NZ_CP051428:1024403-1024642 [Paenibacillus sp. UniB2]
MQWQLQDAKNQLSSVVKKAADEGPQMITVRGMPAAVVLSMEEYQRLTKPKTRLTDFFKDSPLHDLDLDRSQDTAREVEL

Nucleotide

• Length: 240 bp

>AT154072 NZ_CP067307:4797120-4797185 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT