Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4331328..4331986 Replicon chromosome
Accession NZ_CP051427
Organism Klebsiella michiganensis strain X2-1

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag HGI13_RS20570 Protein ID WP_209744128.1
Coordinates 4331328..4331648 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HGI13_RS20575 Protein ID WP_209744132.1
Coordinates 4331669..4331986 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI13_RS20555 4329486..4330055 + 570 WP_049091442.1 recombinase family protein -
HGI13_RS20560 4330302..4330541 - 240 WP_015370245.1 DinI family protein -
HGI13_RS20565 4330622..4331005 + 384 WP_049091441.1 S24 family peptidase -
HGI13_RS20570 4331328..4331648 - 321 WP_209744128.1 TA system toxin CbtA family protein Toxin
HGI13_RS20575 4331669..4331986 - 318 WP_209744132.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HGI13_RS20580 4332005..4332226 - 222 WP_209744136.1 DUF987 domain-containing protein -
HGI13_RS20585 4332235..4332711 - 477 Protein_4049 RadC family protein -
HGI13_RS20590 4332724..4333182 - 459 WP_209744139.1 antirestriction protein -
HGI13_RS20595 4333262..4333498 - 237 Protein_4051 DUF905 domain-containing protein -
HGI13_RS20600 4333576..4333986 - 411 WP_139949634.1 hypothetical protein -
HGI13_RS20605 4334075..4334689 - 615 WP_209744142.1 hypothetical protein -
HGI13_RS20610 4334686..4335390 - 705 WP_209744144.1 WYL domain-containing protein -
HGI13_RS20615 4335592..4336425 - 834 WP_209744147.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4262215..4336425 74210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-104)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12134.14 Da        Isoelectric Point: 7.8586

>T154062 WP_209744128.1 NZ_CP051427:c4331648-4331328 [Klebsiella michiganensis]
MKTLPATTLRTAKPCPSTVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAINFLVEKYELIRIDRKGC
SWQEQSPFITAVDILKARRAMREMRT

Download         Length: 321 bp

>T154062 NZ_CP067307:c3796768-3796433 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAAAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11920.65 Da        Isoelectric Point: 8.1359

>AT154062 WP_209744132.1 NZ_CP051427:c4331986-4331669 [Klebsiella michiganensis]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFIRQMKSMLTSGEMNPRYAHCVTLYH
NGFTCEADTLGSCGYVYITVYPTQR

Download         Length: 318 bp

>AT154062 NZ_CP067307:c3797016-3796768 [Escherichia coli]
ATGATCCACAGTAGCATAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References